Diasulin 30/70 Vial | 100IU/ml

✔️ Pharmacology

Diasulin (Human Insulin rDNA) lowers blood glucose by promoting glucose uptake into muscle and fat cells and inhibiting hepatic glucose output.

Onset of action: ~30 minutes

Peak plasma level: 1–3 hours

Duration of action: 18–24 hours
Insulin has a very short plasma half-life and does not significantly bind to plasma proteins.

✔️ Composition

30/70 formulation:
Each ml contains Insulin Human (rDNA) USP 100 IU = 30% Regular Insulin + 70% Isophane Insulin.

50/50 formulation:
Each ml contains Insulin Human (rDNA) USP 100 IU = 50% Regular Insulin + 50% Isophane Insulin.

✔️ Dosage & Administration

The dosage is individualized according to patient requirements.

Typical maintenance dose (Type 1 Diabetes):
0.5–1.0 IU/kg/day (in divided doses)
Children (pre-pubertal): 0.7–1.0 IU/kg/day
Type 2 Diabetes (initial): 0.3–0.6 IU/kg/day

Note: Each injection should be followed within 30 minutes by a carbohydrate-containing meal or snack.
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।

✔️ Side Effects

Most common: Hypoglycemia (dose-related)

Local effects: Lipodystrophy at the injection site

Systemic hypersensitivity: Rash, itching, angioedema, breathing difficulty, hypotension (rare but serious)

Transient edema may occur at therapy initiation.

✔️ Administration Instructions

Administer subcutaneously, preferably in the abdominal wall, thigh, gluteal, or deltoid region.

Rotate injection sites within the same area to prevent lipodystrophy.

Abdominal injections ensure faster absorption.

Before use, gently mix the suspension by rolling the cartridge between the hands until uniformly white and cloudy.

Do not use if frozen, discolored, or with clumps or solid particles.

Always remove the needle after injection to prevent leakage and potency loss.

✔️ Insulin dosage may require adjustment during:

• Illness, infection, or fever (↑ requirement)
• Renal or hepatic impairment (↓ requirement)
• Changes in physical activity or diet
• Transition to a different insulin formulation

✔️ Drug Interactions

May decrease insulin requirement:

Oral hypoglycemics, MAOIs, ACE inhibitors, non-selective beta-blockers, salicylates, alcohol

May increase insulin requirement:

Thiazides, corticosteroids, thyroid hormones, beta-sympathomimetics, growth hormone, danazol

Caution:

Beta-blockers may mask symptoms of hypoglycemia.

Alcohol may prolong or intensify hypoglycemia.

✔️ Use in Pregnancy & Lactation

• Insulin does not cross the placenta; safe during pregnancy.
• Insulin requirements decrease in the first trimester and increase in later stages.
• After delivery, insulin needs return to pre-pregnancy levels.
• Safe for lactating mothers, but dosage adjustment may be necessary.

✔️ Precautions & Warnings

• Inadequate dosing or discontinuation may cause hyperglycemia or ketoacidosis (life-threatening in Type 1 diabetes).
• Overdosage may cause hypoglycemia—manage with glucose or glucagon as appropriate.
• Switching between insulin types or brands should be done under medical supervision.
• Before long travel or a time-zone change, consult a physician for dosage timing adjustments.

✔️ Contraindications

Hypoglycemia

Hypersensitivity to human insulin or any excipient

✔️ Precautions & Warnings

Mild hypoglycemia: Treat with oral glucose or sugar.

Severe hypoglycemia: Treat with Glucagon (0.5–1 mg IM/SC) or IV glucose; follow with oral carbohydrate intake after recovery to prevent relapse.

✔️ Storage Conditions

• Store between 2°C and 8°C (refrigerated). Do not freeze.
• Keep in outer carton to protect from light.
• In-use cartridge:
• Up to 6 weeks below 25°C, or
• Up to 4 weeks below 30°C.
• Always mix thoroughly before use by rolling gently between palms.