Uroflo 0.4mg 10pcs - ePharma
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Uroflo 0.4mg 10pcs

Generic: Tamsulosin HCl

Type: Capsule

Pack Size: 10 Pcs

Generic Name: Tamsulosin Hydrochloride 0.4mg

Manufacturer/Distributor: Beximco Pharmaceuticals Ltd. 


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Description:

Indications

Tamsulosin Hydrochloride is a treatment for the symptoms of benign prostatic hyperplasia (BPH).

Pharmacology

Tamsulosin, a selective alpha1 adrenoceptor blocker, selectively blocks alpha1 A adrenoceptors in the human prostate. When these adrenoceptors are blocked, the smooth muscle in the bladder neck, and prostate relaxes, resulting in increased urine flow and a reduction in BPH symptoms. Under fasting conditions, oral administration of Tamsulosin hydrochloride capsule 0.4mg results in nearly complete absorption (90 percent). The time to maximum concentration (Tmax) is four to five hours when given without food, and six to seven hours when given with food. Tamsulosin hydrochloride binds to human plasma protein extremely well (94% to 99%). Tamsulosin hydrochloride is extensively metabolized in the liver by cytochrome P 450 proteins, with less than 10% of the measurements excreted in pee as unaltered shape. Tamsulosin hydrochloride has a plasma disposal half-life of five to seven hours after intravenous or oral administration of an immediate-release definition. Because of the retention rate-controlled pharmacokinetics with Prostam capsules, the clear half-life of Tamsulosin hydrochloride is around 9 to 13 hours in solid volunteers and 14 to 15 hours in the target population.

Dosage & Administration

  • Tamsulosin Hydrochloride 0.4 mg (one capsule) once daily, after dinner. If necessary, the dose can be increased after 2 to 4 weeks to Tamsulosin Hydrochloride 0.8 mg (two capsules) once daily. 
  • If Tamsulosin Hydrochloride administration is stopped or interrupted for a few days at either the 0.4 mg or 0.8 mg dose, therapy should be restarted with the 0.4 mg (one capsule) once daily dose. 
  • In a standing or sitting position, swallow the capsule whole with a glass of water (about 150 ml). 
  • Crunching or chewing the capsule will interfere with the modified release of the active ingredient.

Interaction

Tamsulosin, a selective alpha1 adrenoceptor blocker, selectively blocks alpha1 A adrenoceptors in the human prostate. When these adrenoceptors are blocked, the smooth muscle in the bladder neck, and prostate relaxes, resulting in increased urine flow and a reduction in BPH symptoms. Under fasting conditions, oral administration of Tamsulosin hydrochloride capsule 0.4mg results in nearly complete absorption (90 percent). The time to maximum concentration (Tmax) is four to five hours when given without food, and six to seven hours when given with food. There were no interactions at the level of hepatic metabolism observed during in vitro studies with liver microsomal fractions (typical of the cytochrome P450-linked drug-metabolizing enzyme system) involving amitriptyline, salbutamol, glibenclamide, and finasteride. Diclofenac and warfarin, on the other hand, have the potential to increase the rate of Tamsulosin elimination.

Contraindications

Tamsulosin hydrochloride is not recommended for patients who are extremely sensitive to it, have a history of orthostatic hypotension, or have severe hepatic insufficiency. As with other alpha1 blockers, a decrease in blood weight can occur in individual cases amid Tamsulosin treatment, resulting in syncope on occasion. At the first signs of orthostatic hypotension (discombobulation, shortcoming), the quiet should sit or lie down until the indications have vanished. They should also be warned to avoid situations that could lead to harm (like driving, working apparatus, or performing dangerous errands). When Tamsulosin treatment began, the patient should be monitored to rule out the presence of other conditions that can cause the same symptoms as a Kind of Prostatic Hyperplasia. Advanced rectal examination, as well as the vital assurance of Prostate Specific Antigen (PSA), should be performed before treatment and at regular intervals afterward.

Side Effects

The following negative reactions have been reported while using Tamsulosin: drowsiness, unusual ejaculation, and; less frequently, migraine, asthenia, postural hypotension, and palpitations.

Pregnancy & Lactation

Utilize Tamsulosin in pregnancy and lactation isn't prescribed.

Precautions & Warnings

Seldom, transitory postural side effects have happened amid orthostatic incitement testing after the primary dosage. Utilization in patients with micturition syncope isn't advised. Effects on the capacity to drive and utilize machines: No information is accessible on whether Tamsulosin antagonistically influences the capacity to drive or work machines. In any case, in this regard, patients ought to be mindful of the truth that tipsiness can happen.

Storage Conditions

Keep it cool and dry, below 30°C, and out of direct sunlight.

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Check our pricing section for Uroflo 0.4mg 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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