Relaxo 25mg 10Pcs

Uses of Relaxo 25:

• Treatment of spinal cord injury
• Treatment of Stroke
• Treatment of Cerebral palsy
• Treatment of Multiple sclerosis

Side Effects of Relaxo 25:

The most frequently occurring side effects of Relaxo 25 have been drowsiness,

• Dizziness
• Weakness
• General malaise
• Fatigue
• Diarrhea

How to use Relaxo 25:

Take Relaxo 25 according to your doctor's instructions.

Indications of Relaxo 25:

Relaxo 25 is used to control clinical spasticity resulting from upper motor neuronal disorders, such as stroke, spinal cord injury, cerebral palsy, or multiple sclerosis. It may improve residual function in patients with presumably reversible spasticity. Long-term use of Dantrolene is justified if it reduces painful or disabling spasticity, decreases required nursing care, or relieves bothersome spasticity symptoms. Dantrolene can also be given orally to prevent malignant hyperthermia in known or suspected susceptible patients undergoing surgery. After a malignant hyperthermic crisis, Dantrolene can be administered orally to prevent the recurrence of symptoms. It is not effective in treating skeletal muscle spasms resulting from rheumatic disorders.

Pharmacology

Dantrolene induces skeletal muscle relaxation by directly affecting the muscle's contractile response beyond the myoneural junction. It likely disrupts the release of calcium from the sarcoplasmic reticulum, leading to the dissociation of excitation-contraction coupling in skeletal muscle.

Dosage & Administration of Relaxo 25:

For Use in Chronic Spasticity: 

Adults: 

The following gradual titration schedule is suggested. Some patients will not respond until the higher daily dosage is achieved. Each dosage level should be maintained for seven days to determine the patient's response. If no further benefit is observed at the next higher dose, the dosage should be decreased to the previous lower dose.

• Starting dose is 25 mg twice per day and it can be increased to 25-50 mg per day per week. The maximum accepted dosage is 400 mg per day.

Pediatric Patients: 

The following gradual titration schedule is suggested. Some patients will not respond until the higher daily dosage is achieved. Each dosage level should be maintained for seven days to determine the patient's response. If no further benefit is observed at the next higher dose, the dosage should be decreased to the previous lower dose.

• 0.5 mg/kg once daily for seven days, then 0.5 mg/kg 3 times for 7 days, 1 mg/kg 3 times for 7 days, and 2 mg/kg 3 times a day, Therapy with a dose of 4 times daily may be necessary for some individuals

For Malignant Hyperthermia:

• Preoperatively: Administer 4 to 8 mg/kg/day of oral Dantrolene in 3 or 4 divided doses for one or two days prior to surgery, with the last dose being given approximately 3 to 4 hours before scheduled surgery with a minimum of water.
• Post-Crisis Follow-up: Oral Dantrolene should also be administered following a malignant hyperthermia crisis, in doses of 4 to 8 mg/kg per day in four divided doses, for a one to three-day period to prevent recurrence of the manifestations of malignant hyperthermia.

Interaction

Drowsiness may occur with Dantrolene therapy, and the concomitant administration of CNS depressants such as sedatives and tranquilizing agents may result in further drowsiness. Hepatotoxicity has occurred more often in women over 35 years of age receiving concomitant estrogen therapy. 

Contraindications

Active hepatic disease, such as hepatitis and cirrhosis.

Pregnancy & Lactation:

Pregnancy Category C. Dantrolene capsules should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Dantrolene should not be used in nursing mothers

Precautions & Warnings

Relaxo 25 may cause liver damage, so therapy should be stopped if no benefit is seen within 45 days. Patients should avoid driving or hazardous activities while taking it. Liver function tests should be done before starting therapy and at intervals during treatment. If symptoms of liver disease occur, Dantrolene should be discontinued. Caution is needed in the concomitant use of tranquilizers and in patients with liver or lung problems. Females and those over 35 years old are at higher risk for liver disease with Dantrolene use.

Storage Conditions

 Store in a cool & dry place, protected from light.