Nintoin Suspension 100ml

Uses of Nintoin Suspension

• Treatment of Bacterial infections of the urinary tract

How does Nintoin Suspension work?

Nintoin Suspension effectively treats and prevents urinary tract infections by killing bacteria present in the urethra, bladder, and/or kidneys. It mainly acts by disrupting the production of genetic material present in the bacterial cell.

Side Effects of Nintoin Suspension

• Skin rash
• Fever and chills
• Burning or tingling sensation
• Headache
• Drowsiness
• Diarrhea
• Excessive gas in the stomach

Quick Suggestions:

• Nintoin Suspension treats and prevents uncomplicated urinary tract infections.
• Finish the prescribed course of medicine, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
• Take it with food to avoid nausea, which is a common side effect.
• It can turn your urine a dark yellow or brown color. This is normal and nothing to worry about.
• Do not take it for longer or more often than prescribed by your doctor.

Indication of Nintoin Suspension

Nintoin Suspension is an antibiotic medicine. It is used for the treatment and prevention of uncomplicated urinary tract infections.

Pharmacology

Nitrofurantoin is an antibacterial agent that works particularly well for infections of the urinary tract. Extremely solvent in urination, nitrofurantoin may give poop a brown hue. Ribosomal proteins and other macromolecules produced by bacteria are inactivated or altered by nitrofurantoin. It has been demonstrated that nitrofurantoin is effective against pursuing microscopic organisms: Grass-Feeding Aerobes Enterococcus faecalis, Staphylococcus aureus, Streptococcus agalactiae, Gather D streptococci, and Viridans gather streptococci are among the staphylococci that are Coagulase-negative and include Staphylococcus epidermidis. Escherichia coli, Citrobacter amalonaticus, Citrobacter diversus, Citrobacter freundii, Klebsiella oxytoca, and Klebsiella ozaena are examples of Gram-negative Aerobes.

Dosage & Administration of Nintoin Suspension

The recommended dosage of Nitrofurantoin suspension for children is 5-7 mg/kg/day, divided into four doses per day. However, it is contraindicated for use in infants under one month of age. The average doses for pediatric patients are as follows:

• For children weighing 7 to 11 kg: Administer ½ (2.5 ml) teaspoonfuls four times daily.
• For children weighing 12 to 21 kg: Administer 1 (5 ml) teaspoonful four times daily.
• For children weighing 22 to 30 kg: Administer 1½ (7.5 ml) teaspoonfuls four times daily.
• For children weighing 31 to 41 kg: Administer 2 (10 ml) teaspoonfuls four times daily.

Treatment should be continued for one week or at least 3 days after the urine becomes sterile. In some cases, for long-term suppressive therapy in children, lower doses of 1 mg/kg per 24 hours may be sufficient. This dose can be given as a single dose or divided into two doses.

Always take Bevon Suspension as advised by the physician. Shake well before use. Do not exceed the recommended daily dosage. Use a measuring cup or a spoon to properly measure the dose. Do not take Bevon Suspension if you are allergic to any of its components.

Interaction

When Nitrofurantoin is taken together with antacids containing Magnesium Trisilicate, it can interfere with the absorption and effectiveness of certain uricosuric medicines, such as Probenecid and Sulfinpyrazone. Uricosuric medicines are used to treat conditions like gout by increasing the excretion of uric acid from the body.

The presence of Magnesium Trisilicate in antacids can reduce the absorption rate and extent of these uricosuric medicines, making them less effective in lowering uric acid levels. Additionally, Nitrofurantoin can also be affected by the interaction with Magnesium Trisilicate, as it can limit the secretion of Nitrofurantoin in the renal tubules (part of the kidney involved in urine formation and excretion).

To ensure the optimal effectiveness of both Nitrofurantoin and uricosuric medicines, it is advisable to separate their administration. It is recommended to take Nitrofurantoin and uricosuric medicines at different times, with an appropriate time interval between them. This helps to avoid any potential interactions and allows for proper absorption and effectiveness of each medication.

Contraindications

• Severe Renal Impairment: If you have severe renal impairment, such as anuria (absence of urine production), oliguria (reduced urine production), significantly elevated serum creatinine levels, or creatinine clearance (CrCl) below 60 ml/min, the use of nitrofurantoin may be contraindicated or require dosage adjustment. Your healthcare provider will determine the appropriate course of action.
• Hypersensitivity to Nitrofurans: If you have a known hypersensitivity or allergic reaction to nitrofurans or any components of nitrofurantoin, its use should be avoided. Allergic reactions can range from mild skin rashes to severe systemic reactions, including anaphylaxis.
• G6PD Deficiency: Nitrofurantoin use should be avoided in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD deficiency is an enzyme deficiency that can lead to hemolysis (destruction of red blood cells) when exposed to certain medications, including nitrofurantoin.
• Infants Under 3 Months of Age: Nitrofurantoin is not recommended for use in infants younger than 3 months old. Safety and efficacy data in this age group are limited.
• Pregnancy at Term, During Labor and Delivery, or Imminent Onset of Labor: Nitrofurantoin should not be used in pregnant women at term (near the end of pregnancy), during labor and delivery, or when the onset of labor is imminent. There is a potential risk to the baby during these stages.

Pregnancy & Lactation

Pregnancy Category B. Limited and inconclusive studies have been conducted on the use of this medication in pregnant women. It should only be used during pregnancy if it is absolutely necessary. Small amounts of nitrofurantoin have been detected in human breast milk. Considering the potential for significant side effects in nursing infants under one month old, a decision should be made regarding whether to discontinue breastfeeding or discontinue the medication, taking into account the importance of the drug to the mother.

Precautions & Warnings

In elderly patients, caution should be exercised when using Nitrofurantoin. It is important to monitor hepatic (related to the liver) and pulmonary (related to the lungs) function during prolonged therapy to ensure the medication is well-tolerated and does not cause any adverse effects.

If a patient has pre-existing pulmonary, hepatic, neurological, or allergic disorders or a predisposition to peripheral neuropathy (damage to the nerves in the extremities), special care should be taken when considering the use of Nitrofurantoin. This includes individuals with conditions such as renal impairment (kidney dysfunction), anemia, diabetes mellitus (high blood sugar), electrolyte imbalance, debility (weakness), and vitamin B deficiency.

If signs of peripheral neuropathy, such as numbness, tingling, or pain in the hands or feet, occur during treatment with Nitrofurantoin, the medication should be discontinued.

Regarding lactation, Nitrofurantoin enters breast milk. Therefore, it is recommended to discontinue the drug or avoid nursing while taking Nitrofurantoin to prevent potentially adverse effects on the breastfed infant.

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children.