Clinex Plus Gel (1.2%+0.025%)

Uses of Clinex Plus Gel

Acne (Pimple)

How does Clinex Plus Gel work?

Clindamycin, an antibiotic that penetrates the skin to eliminate acne-causing bacteria, and Tretinoin, a form of vitamin A that reduces skin oil production, promote skin renewal, and keeps pores open.

Side Effects of Clinex Plus Gel

Common side effects may include dryness, skin redness, scaling, burning sensation, skin exfoliation, inflammation of the throat and nasal passages, cough, and sinus inflammation.

Overdosage of Clinex Plus Gel

Overdosing on Clinex Plus Gel can lead to skin irritation, redness, and dryness. In case of excessive application, rinse the affected skin with warm water. If irritation persists, discontinue the use of Clinex Plus Gel for a few days or until the irritation subsides. If symptoms persist or worsen, consult your doctor. In some cases, excessive use may result in stomach pain, diarrhea, nausea, or vomiting. If you experience these symptoms, contact your doctor immediately.

Quick Suggestions:

• While using Clinex Plus Gel, it's crucial to avoid sun exposure to prevent increased sensitivity and the risk of sunburn.
• Protect your skin with clothing and sunscreen when outdoors. Regular exercise is beneficial for mood and self-esteem, but be sure to shower afterward to prevent sweat-induced acne irritation.
• Maintain clean hair and avoid strands falling across the face. Remove makeup before bedtime and steer clear of skin-irritating products like harsh soaps, cleansers, and hair products.
• Apply other lotions or cosmetics 30 minutes after using Clinex Plus Gel to avoid reducing its effectiveness. Avoid contact with the nose, mouth, eyes, or ears, and if accidental contact occurs, rinse with water.
• Refrain from squeezing or picking spots to prevent worsening and permanent scarring.

Pimple:

Acne, also known as pimples, is a prevalent skin condition resulting from the blockage of hair follicles by dead skin cells and oil. It commonly affects individuals of all ages, with teenagers being the most susceptible. Symptoms of acne encompass pus-filled pimples, non-inflamed blackheads, as well as red, large, and tender bumps. Treatment options for acne involve the use of specific creams, cleansers, and antibiotics.

Pharmacology

Clinex Plus Gel is a combination of the lincosamide antibiotic Clindamycin phosphate and the retinoid Tretinoin. Clindamycin operates by binding to the 50s ribosomal subunit of susceptible bacteria, hindering the elongation of the peptide chain and suppressing bacterial protein synthesis. This action inhibits the activity of Propionibacterium acne, reducing the occurrence of acne. Tretinoin, on the other hand, decreases the cohesiveness of follicular epithelial cells and enhances turnover, helping to bring comedones to the surface. The synergistic effect of these components makes Clinex Plus Gel effective in treating acne.

Dosage & Administration:

Wash your hands before and after applying Clinex Plus Gel. Apply Clinex Plus Gel onto the affected area as advised by the doctor. In case Clinex Plus Gel comes in contact with the eyes accidentally, rinse with water thoroughly.

Interaction

Drug Interactions:

• Antibiotics: Clinex Plus Gel may interact with antibiotics like erythromycin and metronidazole.
• Blood Thinner: Interaction with blood thinner warfarin.
• Keratolytic Agents: Interaction with keratolytic agents like benzoyl peroxide and salicylic acid.
• Skeletal Muscle Relaxants: Interaction with skeletal muscle relaxants like atracurium and cisatracurium.

Drug-Food Interaction: If you are taking grapefruit juice or alcohol, inform your doctor before using Clinex Plus Gel15 gm.

Drug-Disease Interaction: If you have intestine problems or eczema, inform your doctor before using Clinex Plus Gel 15 gm.

Contraindications

Clindamycin and Tretinoin should not be administered to individuals who are hypersensitive to Clindamycin or Tretinoin or any other component of the Gel.

Pregnancy & Lactation

It is not known whether Clindamycin or Tretinoin is excreted in human milk. Exercise special caution while applying Clindamycin or Tretinoin to a nursing mother.

Precaution & Warnings:

Before using Clinex Plus Gel 15gm, it's important to inform your doctor if:

• Allergic Reactions: If you are known to be allergic to Clinex Plus Gel 15 gm or any other medicines, notify your doctor.
• Inflammatory Conditions: If you have chronic inflammatory bowel disease (e.g., Crohn’s disease or ulcerative colitis) or other acute inflammatory conditions of the skin (e.g., folliculitis), especially around the mouth (perioral dermatitis).
• Sun Sensitivity: Avoid sun exposure while using Clinex Plus Gel 15 gm, as it may increase skin sensitivity to sunlight and cause sunburn. Wear protective clothing and use sunscreen when going out.
• History of Colitis: If you have a history of colitis (chronic digestive disease) with past antibiotic use, characterized by prolonged or significant diarrhea or abdominal cramps.
• Skin Conditions: Do not apply Clinex Plus Gel 15gm to cuts, open wounds, broken, sunburnt, or sensitive skin areas.
• Intestinal Issues or Eczema: Inform your doctor if you have intestine problems or eczema before using Clinex Plus Gel 15 gm.
• Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, inform your doctor before using Clinex Plus Gel 15gm.

Storage Conditions

Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.