Unicort-N Cream

Indications

This preparation is indicated in allergic skin conditions, anal or vulvar itching, anal itching, burns, eczema, infected wounds and sores, pain and itching due to sunburn, itchy skin conditions , pruritus, pruritus and eczema, seborrheic and purulent dermatitis, seborrheic dermatitis , Ulcers, Vaginal or rectal irritation, Sores

Pharmacology

Hydrocortisone is a corticosteroid used with anti-inflammatory and immunosuppressive effects. Its anti-inflammatory effect is due to blocking the migration of neutrophils and reversing the increased capillary permeability. It can also be used as a replacement therapy in adrenal cortex insufficiency.

Neomycin is an aminoglycoside antibiotic. It binds to the 30S subunits of bacterial ribosomes, thereby inhibiting protein synthesis and generating genetic transcription errors that cause cell death. It is active against many Gram-negative bacteria and some Gram-positive bacteria. Lack of activity against fungi, viruses and most anaerobic bacteria

Dosage & Administration

Adult: Apply this preparation into the affected area as directed by physician.

Interaction

Hydrocortisone: Thiazides can cause corticosteroid-induced hyperglycemia and hypokalaemia. Increased incidence of peptic ulcer or gastrointestinal bleeding with concomitant NSAID therapy. The response to anticoagulants is impaired. It is necessary to increase the dose of antihypertensive and antihypertensive drugs. Reduction of serum cones of salicylates and anti-infective agents. Ethanol may increase irritation of the stomach lining. Reduced efficacy with concomitant use of carbamazepine, phenytoin, primidone, barbiturates and rifampicin. The mutual inhibition of metabolism between ciclosporin and corticosteroids increases the plasma cone of both drugs. Increased effect in women taking estrogen or oral contraceptives.

Neomycin: additive nephrotoxic and neurotoxic effects with other aminoglycosides (eg paromomycin), bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin and viomycin. Increased toxicity with potent diuretics (eg, ethacrynic acid, furosemide). May interfere with the absorption of other drugs (eg, phenoxymethylpenicillin, digoxin, methotrexate, and some vitamins). May reduce CO efficiency. May enhance the effects of acarbose. May enhance the effect of non-depolarizing muscle relaxants. May counteract the parasympathetic effects of neostigmine and pyridostigmine. May increase the risk of hypocalcaemia in patients receiving bisphosphonates. May change INR when co-administered with anticoagulants. Can disable oral typhoid vaccine.

Contraindications

Viral/ fungal infections, tubercular or syphilitic lesions, bacterial infections unless used in conjunction with appropriate chemotherapy.

Side Effects

Burning, itching, irritation, hypopigmentation, skin atrophy, striae.

Pregnancy & Lactation

Pregnancy Category C. Animal reproduction studies have shown adverse effects on the fetus and there are no adequate and well-controlled studies in humans, but the potential benefits may justify the use of the drug in patients. pregnant women despite the potential risks.

Precautions & Warnings

CHR hypertension, DM, epilepsy, elderly, patients on prolonged therapy. Gradual withdrawal, pregnancy and lactation.