Epam 5mg 10pcs

Indications

Insomnia treatment in the short term, infantile spasms

Pharmacology

Nitrazepam is a benzodiazepine with a pronounced sleep-inducing activity. It depresses the reticular-activating system in the brainstem by enhancing the inhibitory effect of GABA on brain cells, thus preventing excessive brain activity.

Dosage & Administration

Short-term management of insomnia:

• Adult: 5 mg at night; increase to 10 mg if necessary.
• Elderly: and debilitated patients: ≤normal adult dose.
• Infantile spasms:
• Child: Infants: 125 mcg/kg bid; gradually increase to 250-500 mcg/kg bid.

Interaction

Alcohol, barbiturates, TCAs, phenothiazines, and morphine derivatives all have a CNS depressing impact. Theophylline may counteract the effects. With probenecid, the levels/effects are increased. Rifampicin lowers levels and has fewer side effects. Levodopa effects may be reduced.

Contraindications

Myasthenia gravis, narrow-angle glaucoma, severe respiratory insufficiency, sleep apnoea syndrome, severe hepatic impairment, and porphyria are some of the conditions that can affect people.

Side Effects

Hypotension, palpitation; agitation, aggressiveness, amnesia, ataxia, confusion, delusions, disorientation, dizziness, fatigue, hallucination, hangover, headache, irritability, nightmares, psychoses, rage, restlessness, sedation; rash; changes in libido; constipation, diarrhoea, excessive salivation, heartburn, nausea, vomiting; granulocytopenia, leukopenia; falling, muscle weakness; blurred or double vision; tinnitus (associated with withdrawal); aspiration, increased bronchial secretion, dyspnoea.

Precautions & Warnings

Patients should get 7-8 hours of unbroken sleep after taking the dose to avoid anterograde amnesia. It's possible that it'll affect your capacity to drive or operate machinery. Depression, especially if there is a danger of suicide. A history of substance abuse or severe alcoholism. Insufficiency of the liver and kidneys. Inflammation in the lungs. Patients who are incapacitated. Patients who are prone to falling. Children and the elderly. Lactation and pregnancy.

Storage Conditions

Store below 30°C at a cool and dry place, away from light. Keep out of reach of children.