Tamoxen 20mg Tablet 1 Strip

✔️ Side Effects:

Tamoxen may cause both estrogen-related and general side effects, including:

• Hot flushes, vaginal discharge/bleeding, pruritus vulvae, tumor flare
• Gastrointestinal discomfort, headache, dizziness, fluid retention, hair thinning
• Skin rashes, rare severe reactions like Stevens-Johnson syndrome
• Visual issues: Retinopathy, corneal changes, increased risk of cataracts
• Hematologic changes: Leucopenia, anemia, thrombocytopenia, neutropenia
• Liver dysfunction: Changes in liver enzyme levels, cholestasis, fatty liver
• Reproductive system effects: Endometrial changes, fibroids, ovarian cysts
• Thromboembolic events: DVT, pulmonary embolism

Rarely, elevated triglycerides, potentially leading to pancreatitis

✔️ Dosage & Administration:

Adults (including elderly):
The recommended daily dosage is 20 to 40 mg, taken as a single dose or divided into two doses.

✔️ Drug Interactions:

Coumarin anticoagulants: Concurrent use may increase anticoagulant effect, requiring close monitoring.

Cytotoxic agents: Co-administration may raise the risk of thromboembolic events.

✔️ Contraindications:

Pregnancy: Tamoxen should not be taken during pregnancy.

Hypersensitivity: Not for use in patients allergic to tamoxifen or any of its components.

✔️ Pregnancy & Lactation

Pregnancy: Tamoxen is contraindicated during pregnancy. Although some birth defects and fetal deaths have been reported, no direct link has been established. Patients should avoid pregnancy while taking Tamoxen and for at least two months after stopping. Non-hormonal contraceptives are advised.

Lactation: It’s unclear if tamoxifen is excreted in breast milk. Use is not recommended while breastfeeding. A healthcare provider should assess the importance of continuing the drug for the mother.

✔️ Precautions & Warnings

Menstrual irregularities may occur in premenopausal women.

Increased risk of endometrial cancer has been observed, possibly due to estrogen-like effects of tamoxifen.

Any abnormal gynecological symptoms, especially vaginal bleeding, should be evaluated.

Rare reports of secondary tumors (excluding the endometrium or opposite breast) have been noted; their significance is unclear.

✔️ Storage:

Store at 20–25°C, away from light.