Cotson 10mg 10pcs

Indications

Hydrocortisone is demonstrated for utilizing within the taking after conditions:

Primary or auxiliary adrenocortical insufficiency

Acute adrenocortical insufficiency

Shock lethargic to ordinary therapy

Congenital adrenal hyperplasia

Hypercalcemia related to cancer

Nonsuppurative thyroiditis

Rheumatic Disorders

Dermatologic Illnesses (Unfavorably susceptible States, Serious seborrheic dermatitis, Extreme psoriasis, Pemphigus, Serious erythema multiforme)

Control of serious or debilitating unfavorably susceptible conditions (Bronchial asthma, Contact dermatitis, Atopic dermatitis, Serum affliction, Regular or lasting unfavorably susceptible rhinitis, Sedate touchiness responses, Urticarial transfusion responses, Intense noninfectious laryngeal edema)

Ophthalmic Illnesses (Herpes zoster ophthalmic us, Iritis, iridocyclitis, Chorioretinitis, Diffuse back uveitis and choroiditis, Optic neuritis)

Gastrointestinal Diseases

Fulminating or spread aspiratory tuberculosis when utilized concurrently with fitting antituberculosis.

Pharmacology

The enzyme phospholipase A2 is inhibited by hydrocortisone, which prevents prostaglandin production. Various vasoactive substances generated during inflammation are reduced by hydrocortisone. It also regulates the rate at which proteins are synthesized.

Dosage & Administration

Tablet: The initial dosage of Hydrocortisone Tablets may vary from 20 mg to 240 mg of hydrocortisone per day depending on the specific disease entity being treated. In situations of less severity, lower doses will generally suffice, while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period of time there is a lack of satisfactory clinical response, Hydrocortisone Tablets should be discontinued and the patient transferred to other appropriate therapy. 

It should be emphasized that dosage requirements are variable and must be individualized on the basis of the disease under treatment and the response of the patients. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response. It should be kept in mind that constant monitoring is needed in regard to drug dosage. If, after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually, rather than abruptly.

Injection:

Adult: By IM injection or slow IV injection or infusion. The initial dose of Hydrocortisone sterile powder is 100 mg to 500 mg, depending on the severity of the condition. This dose may be repeated at intervals of 2, 4 or 6 hours as indicated by the patient's response and clinical condition.

Children: By slow IV injection, up to 1 year 25 mg, 1-5 years 50 mg, 6-12 years 100 mg.

Interaction

Inducing hepatic enzymes with drugs like phenobarbital, phenytoin, and rifampin might enhance corticosteroid clearance, requiring higher corticosteroid doses to obtain the desired effect. Drugs like Oleandomycin and Ketoconazole can prevent corticosteroids from being metabolized and so reduce their clearance. To avoid this, the dose of corticosteroid should be titrated.

Contraindications

In individuals with severe systemic fungal infections or known hypersensitivity to any component of this medication, hydrocortisone is contraindicated.

Side Effects

Except with large doses for lengthy periods of time, hydrocortisone is generally well tolerated. It can induce cardiac arrhythmias, esophageal candidiasis, menstruation irregularities, impaired carbohydrate & glucose tolerance, fluid retention, increased appetite, weight gain, euphoria, mood swings, depression, sleeplessness, acne, and other side effects.

Pregnancy & Lactation

This should be prescribed in pregnancy and lactation only if absolutely required.

Precautions & Warnings

In patients with a history of peptic ulcers, hydrocortisone should be administered with caution since it raises the risk of peptic ulceration. In individuals with congestive heart failure, hypertension, glaucoma, diabetes mellitus, or epilepsy, this medicine should be used with caution.

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.