Dibenol 5mg Tablet 15pcs

✔️ Side Effects of Dibenol 5

Severe hypoglycemic reactions, including coma, seizure, or neurological impairment, are rare but can occur. Other common side effects may include mild hypoglycemia symptoms.

✔️ Dosage & Administration of Dibenol 5

There is no fixed dosage regimen for Glibenclamide. The following guidelines are typically recommended:

• Initial dose: 2.5 to 5 mg daily, taken with breakfast or the first main meal.
• For sensitive patients: Start with 1.25 mg daily.
• Maintenance dose: 1.25 to 20 mg daily, either as a single dose or divided doses.
• Dosage increases should be made in increments of no more than 2.5 mg per week, based on blood glucose response.
• Maximum dose: Do not exceed 20 mg daily.

Use as directed by a registered healthcare professional.

✔️ Uses of Dibenol 5

• Type 2 diabetes mellitus

✔️ Interaction

The hypoglycemic effect of Glibenclamide may be enhanced by the following drugs:

• Nonsteroidal anti-inflammatory agents (NSAIDs), ACE inhibitors, fluoxetine, clarithromycin, salicylates, sulfonamides, chloramphenicol, probenecid, monoamine oxidase inhibitors (MAOIs), and beta-adrenergic blockers.
• Risk of hypoglycemia: If these drugs are used alongside Dibenol, close monitoring for hypoglycemia is required.
• Hyperglycemic drugs: Thiazides, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid may counteract the effects of Glibenclamide and may lead to hyperglycemia.
• Oral miconazole: May interact with oral hypoglycemic agents like Glibenclamide and lead to severe hypoglycemia.

✔️ Glibenclamide should not be used in patients with:

• Known hypersensitivity to Glibenclamide or any of its excipients.
• Type 1 diabetes mellitus or diabetic ketoacidosis, with or without coma. These conditions should be treated with insulin.

✔️ Pregnancy & Lactation

• Pregnancy Category C: No significant evidence of harm to the fetus in human studies, although the drug should only be used when the benefits outweigh potential risks.
• It is not known whether Glibenclamide is transferred to human milk, but other sulfonylureas have been found in breast milk. Caution is recommended when using during lactation.

✔️ Precautions & Warnings

• All sulfonylureas, including Glibenclamide, can cause severe hypoglycemia. Proper patient selection, correct dosing, and adequate instructions are critical to avoid hypoglycemic episodes.

✔️ Storage Conditions

• Store below 30°C, protected from light and moisture.
• Keep out of reach of children.