Methox 10mg Tablet | Methotrexate | ePharma
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Methox 10mg Tablet

Generic: Methotrexate

Type: Tablet

Pack Size: 10 Pcs

Methotrexate hinders the growth of rapidly reproducing cells, notably cancer cells, bone marrow cells, and skin cells. It's employed to treat leukemia and specific cancers affecting the breast, skin, head, neck, lung, or uterus. Additionally, Methotrexate is used for severe psoriasis and rheumatoid arthritis in adults, as well as active polyarticular-course juvenile rheumatoid arthritis in children. It is often prescribed when other medications have proven ineffective.


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Discount Price: ৳ 140.43
MRP: ৳ 151 7% Off

⪼ Save  ৳: 10.57  in this Product


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Description:

Methox 10mg Tablet is prescribed for various conditions. Primarily, it is used to treat severe psoriasis, rheumatoid arthritis that is not responsive to other treatments, and certain types of cancer such as breast cancer and leukemia. Methotrexate belongs to a class of medications called antimetabolites, which work by slowing the growth of cancer cells and skin cells.

In addition to its primary uses, Methotrexate is sometimes employed for conditions like Crohn's disease, multiple sclerosis, and other autoimmune diseases. Patients should be aware of potential risks associated with off-label use and consult their doctor accordingly.

Special precautions include informing the healthcare provider about allergies, current medications, and medical conditions. Methotrexate may require careful monitoring, especially in cases of surgery, and precautions against excessive sunlight exposure due to increased skin sensitivity. Vaccinations during treatment should be discussed with the doctor.

Patients are advised not to alter the dosage without consulting their doctor and to promptly report any side effects. Serious symptoms like blurred vision, seizures, or weakness require immediate medical attention.

Safety Advices


Alcohol
UNSAFE

Taking Methotrexate with alcohol increases the risk of liver damage.


Pregnancy
UNSAFE

Methox 10mg Tablet is highly unsafe to use during pregnancy.
Human and animal studies have shown significant adverse effects on the fetus. Please consult your doctor.


Breastfeeding
UNSAFE

Methox 10mg Tablet is probably unsafe to use during breastfeeding. Please consult your doctor.


Driving
CAUTION

There is no interaction between driving and consuming this drug. So dose alteration is not needed.


Kidney
CAUTION

Caution to be advised in patients with impaired renal function.


Liver
CAUTION

There is no data available. Please consult a doctor before consuming the drug.

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Uses of Methox 10mg Tablet
  • Blood Cancer
  • Bone Cancer
  • Cervical Cancer
  • Ovarian Cancer
  • Testicular Cancer
  • Non-Hodgkin Lymphoma (NHL)
  • Breast Cancer
  • Lung Cancer
  • Head And Neck Cancer
How does Methox 10mg Tablet work?

It has an inhibiting effect on the enzyme tetrahydrofolate dehydrogenase which in turn prevents the synthesis of tetrahydrofolate, a compound necessary for the synthesis of thymidylate, an essential component of DNA.

Side Effects of Methox 10mg Tablet
  • Headache
  • Vomiting
  • Fever
  • Skin Redness
  • Glossitis
  • Nausea
  • Diarrhoea
  • Renal Failure
  • Pharyngitis
  • Dizziness
  • Encephalopathy
  • Seizures
  • Chills
  • Hemorrhage
  • Blurred Vision
Quick Suggestions:
  • Drink plenty of liquids to stay hydrated while taking this  medication.
  • Take folic acid if advised by your doctor. This will help lessen the side effects of this medicine.
  • It may take from weeks to months for Methox 10mg Tablet to work. Keep taking the medication as prescribed.
  • Your doctor may get regular blood test done to monitor your kidney function, liver function and level of blood cells in your blood.
  • Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
  • It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
Indications:

Methox 10mg Tablet is used in the treatment of rheumatoid arthritis and psoriasis.

Pharmacology

Methox 10mg Tablet inhibits the enzyme dihydrofolic acid reductase. This enzyme is essential for converting dihydrofolates into tetrahydrofolates, which are necessary as carriers of one-carbon groups in the synthesis of nucleotides and thymidylate. By interfering with this process, Methox 10mg Tablet disrupts DNA synthesis, repair, and cellular replication.

Tissues that actively proliferate, such as malignant cells, bone marrow, fetal cells, buccal and intestinal mucosa, and cells of the urinary bladder, are generally more sensitive to the effects of Methox 10mg Tablet. When cellular proliferation in malignant tissues surpasses that of most normal tissues, Methox 10mg Tablet may impede the growth of malignant cells without causing irreversible damage to normal tissues.

Dosage & Administration:

The administration of Methotrexate involves taking it orally as tablets. The dosage and schedule depend on the specific condition and individual response. For psoriasis and rheumatoid arthritis, it is often taken once a week. It is crucial to follow the prescribed schedule carefully, as incorrect daily intake can lead to severe side effects.

In case of a missed dose, patients should take it as soon as remembered, but a double dose should not be taken close to the next scheduled dose.

Interaction

Drug-Drug Interactions: Methox 10mg Tablet may interact with:

  • Pain killers (celecoxib, acetaminophen, hydrocodone).
  • Anti-depressant (duloxetine).
  • Immunosuppressants (etanercept).
  • Anti-rheumatoid (adalimumab).
  • Antacid (esomeprazole).
  • Anti-malarial (hydroxychloroquine).

Drug-Food Interactions: Avoid consuming alcohol while on treatment with Methox 10mg Tablet.

Drug-Disease Interactions: Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anemia, liver problems due to alcohol abuse, or chronic liver disease.

Contraindications
  • Allergy
  • Pregnancy
  • Liver Disease
  • Blood Disorder
Pregnancy & Lactation

Pregnancy category X. Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both, and the risk of the use of the drug in pregnant women outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Precautions & Warnings

Talk to your doctor before taking Methox 10mg Tablet if you:

  • Have or had liver or kidney problems.
  • Have ulceration in the stomach or bowels.
  • Are in poor general condition.
  • Have received any vaccinations or are due to have any vaccinations?
  • Have diabetes, ascites (fluid in the stomach area), lung problems, or fluid in the lungs.
Storage Conditions

Storage should be in a tightly closed container at room temperature, away from children. Disposal should be done through medicine take-back programs to prevent accidental consumption.

Frequently Asked Questions (FAQ)

Methotrexate showed a promising effect on the risk of type 2 diabetes

Yes, Methox 10mg Tablet may affect fertility in both males and females. It may cause a decrease in sperm count in males and menstrual disturbances in females. No need to worry, these effects are reversible and disappear once the therapy is discontinued.

Regular blood tests will help your doctor to check your response to Methox 10mg Tablet and monitor you for side effects. You will need to regularly check your liver function and your blood counts (white blood cells, red blood cells and platelets). Your doctor may also order additional tests depending on the results.
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Check our pricing section for Methox 10mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.
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