Xenobese 120mg 24pcs Capsule

Uses of Xenobese 120

• Obesity

Side Effects of Xenobese 120

Common gastrointestinal side effects include oily spotting from the rectum, flatulence, fecal urgency, oily or fatty stool, abdominal discomfort, etc. Rare side effects may include influenza, anxiety, headache, fatigue, and hypersensitivity reactions such as pruritus, exanthema, urticaria, angioedema, and anaphylaxis.

How does Xenobese 120 work?

Xenobese 120 is a lipase inhibitor that works in the stomach and small intestine by blocking the absorption of fat from food.

Quick Suggestions:

• Use Xenobese 120 to aid weight loss along with regular physical activity and a healthy diet.
• Take it during or up to 1 hour after each meal.
• Skip your dose if you miss a meal or if your meal contains no fat.
• A multivitamin supplement containing vitamins A, D, and K is recommended when taking Xenobese 120.
• It should not be taken for longer than six months without a doctor's advice.

Indication of Xenobese 120

• Xenobese 120 is used in the treatment of obesity by blocking the absorption of fats from the small intestines and stomach.

Pharmacology

Orlistat is a potent, specific, and long-acting lipase inhibitor. It exerts its therapeutic activity in the lumen of the stomach and upper small intestine by forming a covalent bond with the active serine site of gastric and pancreatic lipases. The inactivated enzyme is thus rendered unable to hydrolyze dietary fats in the form of triglycerides into absorbable free fatty acids and monoglycerides. As undigested triglycerides cannot be absorbed, a caloric deficit arises which has a positive effect on weight control. Systemic absorption of orlistat is therefore not needed for the activity. At the recommended therapeutic dose of 120 mg three times a day, orlistat inhibits dietary fat absorption by approximately 30%.

Dosage & Administration of Xenobese 120

The recommended dose of Orlistat is one 120 mg capsule to be taken immediately before, during, or up to one hour after each main meal. If a meal is missed or contains no fat, the dose of Orlistat should be omitted. Doses of Orlistat above 120 mg three times daily have not been shown to provide additional benefits. The effect of Orlistat results in an increase in fecal fat 24-48 hours after dosing. Upon discontinuation of therapy, fecal fat content usually returns to pretreatment levels within 48-72 hours.

Administration:

• Should be taken with food. Take immediately before, during, or up to 1 hour after each main meal. If a meal is missed or contains no fat, the dose may be omitted.

Overdose Effects of Xenobese 120

Single doses of 800 mg Adiponil and multiple doses of up to 400 mg three times a day for 15 days have been studied in normal-weight and obese subjects without significant adverse findings. Should a significant overdose of Adiponil occur, it is recommended that the patient be observed for 24 hours. Based on human and animal studies, systemic effects attributable to the lipase-inhibiting properties of Adiponil should be rapidly reversible.

Interaction

Reduction in cyclosporine plasma levels when Adiponil was coadministered with cyclosporine. Adiponil inhibited the absorption of a vitamin E acetate supplement. The effect of Adiponil on the absorption of supplemental vitamin D, vitamin A, and nutritionally-derived vitamin K is not known. Hypothyroidism has been reported in patients treated concomitantly with Adiponil and levothyroxine. Patients treated concomitantly with Adiponil and levothyroxine should be monitored for changes in thyroid function. Administer levothyroxine and Adiponil at least 4 hours apart. Vitamin K absorption may be decreased with Adiponil. Patients on chronic stable doses of warfarin who are prescribed Adiponil should be monitored closely for changes in coagulation parameters. Convulsions have been reported in patients treated concomitantly with Adiponil and antiepileptic drugs. Patients should be monitored for possible changes in the frequency and/or severity of convulsions.

Contraindications

Chronic malabsorption syndrome, cholestasis, lactation.

Pregnancy & Lactation

Orlistat is a Pregnancy Category X drug and is contraindicated during pregnancy. Caution should be exercised when Orlistat is administered to a nursing woman.

Precautions & Warnings

Organic causes of obesity (e.g., hypothyroidism) should be excluded before prescribing Adiponil. Adiponil and cyclosporine should not be coadministered. Cyclosporine should be taken at least 2 hours before or after Adiponil in patients taking both drugs. Cyclosporine levels should be measured and frequently monitored. The decrease in body weight with Adiponil therapy may be less in type II diabetic patients than in non-diabetic patients. Antidiabetic drug treatment should be closely monitored during Adiponil therapy. Patients should be advised to adhere to the dietary recommendations. The daily intake of fat should be distributed between three main meals. Patients should be strongly encouraged to take a multivitamin supplement that contains fat-soluble vitamins to ensure adequate nutrition. The probability of the occurrence of gastrointestinal side effects may increase when Adiponil is taken with a fatty meal.

Storage Conditions

Store in a cool & dry place below 30°C, protect from light & moisture. Keep out of reach of children.

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