Rostil Plus-20pcs Sachet

Uses of Rostil Plus

• Irritable bowel syndrome (IBS)
• Stomach/Abdominal pain

How does Rostil Plus work?

• Rostil Plus is a combination of two drugs, Mebeverine and Ispaghula, used to reduce and relieve symptoms of irritable bowel syndrome (IBS), which include abdominal pain, cramping, bloating, diarrhea, or constipation, as well as abdominal spasmodic pain.
• Mebeverine acts as a spasm and cramps reliever by blocking calcium channels and muscarinic receptors on the smooth muscle. This action inhibits muscle contraction and pain sensation, thereby stopping sudden muscle contractions (spasms) and reducing abdominal pain caused by spasms, cramps, gas formation, bloating, and discomfort.
• Ispaghula, on the other hand, is a laxative. It works by absorbing water, making the stool soft and bulky, and easier to pass. This helps alleviate symptoms associated with constipation and contributes to the overall relief of irritable bowel syndrome.
• In summary, the combination of Mebeverine and Ispaghula in Rostil Plus addresses both the spasm-related and constipation-related aspects of irritable bowel syndrome, providing a comprehensive therapeutic approach.

Side Effects of Rostil Plus

• Bloating
• Constipation
• Dizziness
• Headache
• Stomach Upset
• Insomnia
• Loss of appetite
• Slow heart rate (pulse)
• Urticaria
• Hypersensitivity
• Indigestion

Quick Suggestions:

• Regular exercise and maintaining a healthy weight can contribute to overall digestive health.
• Carbonated and caffeinated drinks can exacerbate symptoms; hence, it's advisable to limit their intake.
• Stress management through activities like yoga or meditation can be beneficial for overall well-being.
• Certain foods may trigger symptoms. It's recommended to avoid high-fat foods, spicy foods, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea, soda, deep-fried, and spicy foods.
• Foods containing probiotics may aid in relieving gas and bloating. Consider incorporating such foods into the diet.

Irritable Bowel Syndrome (IBS):

Irritable Bowel Syndrome (IBS) is a common disorder that affects the large intestine. It is also known by various terms such as irritable colon, spastic colon, spastic colitis, and mucous colitis.

Causes: The exact cause of IBS is unknown, but several factors may contribute to its development, including:

• Acidity
• Stress
• Consumption of carbonated foods and beverages
• Irregular hormone levels
• Certain foods
• Medications

Symptoms: Individuals with IBS may experience a combination of the following symptoms:

1. Abdominal Pain: Discomfort or pain in the abdominal region.
2. Cramps: Sharp or dull cramps in the abdomen.
3. Bloating: Feeling of fullness or tightness in the abdomen.
4. Gas: Increased flatulence or passage of gas.
5. Constipation: Difficulty in passing stools or infrequent bowel movements.
6. Diarrhea: Loose or watery stools.

Contributing Factors:

• Acidity: Imbalance in stomach acid levels.
• Stress: Psychological factors can influence IBS symptoms.
• Dietary Factors: Consumption of certain foods and beverages.
• Hormonal Changes: Irregular hormone levels may play a role.
• Medications: Certain medications may contribute to IBS.

Pharmacology

Mechanism of Action:

• Mebeverine inhibits calcium ion influx into the smooth muscle cells.
• This leads to decreased muscle contractions in the gastrointestinal tract.
• Smooth muscle relaxation results in relief from painful spasms and cramps.

Pharmacokinetics (How it is absorbed, distributed, metabolized, and excreted):

• Absorption: Mebeverine is well-absorbed from the gastrointestinal tract.
• Distribution: It is distributed throughout the body, including the smooth muscles of the gastrointestinal tract.
• Metabolism: Mebeverine undergoes extensive metabolism in the liver.
• Excretion: Metabolites are primarily excreted in the urine.

The onset of Action: The onset of action of Mebeverine is relatively quick, providing relief from symptoms within a short period after administration.

Duration of Action: The duration of action varies, and the medicine may need to be taken as directed by the physician for sustained relief from symptoms.

Overall Effects:

• Relief from painful muscle cramps and spasms in the stomach and intestines.
• Improvement in symptoms associated with irritable bowel syndrome and related conditions.

Dosage & Administration of Rostil Plus

Adult Dose:

Oral Adults: One sachet in the morning and one in the evening half an hour before a meal. If necessary, an additional sachet may be taken before the midday meal.

Child Dose:

Oral Children over 12: One sachet in the morning and one in the evening half an hour before a meal. If necessary, an additional sachet may be taken before the midday meal. Child <12 years: Safety & Efficacy not established.

Administration:

Stir the contents of a sachet into a glass of cold water (approximately 150ml) and drink immediately.

Interaction

• Drug-Drug Interactions: ISPAGHULA HUSK+MEBEVERINE may interact with insulin.
• Drug-Food Interactions: No interactions found or established.
• Drug-Disease Interactions: ISPAGHULA HUSK+MEBEVERINE may have interactions with individuals suffering from acute porphyria (an enzyme deficiency in blood), and heart, kidney, and liver problems.

Contraindications

• Allergy
• Paralytic Ileus

Pregnancy & Lactation

Animal studies have revealed no teratogenicity. However, normal precautions for administering any medication during pregnancy should be followed. Mebeverine does not pass into breast milk once a therapeutic dose is administered.

Precautions & Warnings

Do not take ISPAGHULA HUSK+MEBEVERINE if you are allergic to ‘Mebeverine and Ispaghula’ or any other contents present in it. If you are pregnant or breastfeeding, it is advised to consult a doctor before using ISPAGHULA HUSK+MEBEVERINE. ISPAGHULA HUSK+MEBEVERINE is not recommended for children and adolescents below 12 years of age. If you have had a history of acute porphyria (an enzyme deficiency in blood), heart disease, kidney disease, liver problems, and severe constipation, consult your doctor before taking ISPAGHULA HUSK+MEBEVERINE. Let your doctor know if you use any prescription and non-prescription medications, including vitamins and herbal drugs, before starting ISPAGHULA HUSK+MEBEVERINE. It is important to drink plenty of water or fluids while you are taking ISPAGHULA HUSK+MEBEVERINE.

Storage Conditions

This medication contains salts that are suitable to store only at room temperature, as keeping this medication above or below that, can cause an inadequate effect. Protect it from moisture and light. Keep this medication away from the reach of children. It is advised to dispose of the expired or unused medication, to avoid its inadequate effect.