Ticamet 250 HFA Inhaler

Uses of Ticamet HFA 250 Inhelar

• Asthma
• Chronic obstructive pulmonary disease (COPD)

How Ticamet HFA 250 Inhelar works

Ticamet HFA 250 Inhaler is a combination of two medicines: Salmeterol and Fluticasone Propionate. 

• Salmeterol is a long-acting bronchodilator that works by relaxing the muscles in the airways and widening the airways.
• Fluticasone Propionate is a steroid. It works by stopping the release of certain chemical messengers that cause inflammation (swelling) of the airways. Together, they make breathing easier.

How to use Ticamet HFA 250 Inhaler

• Before using, read the leaflet for instructions.
• Shake the inhaler.
• To discharge the medicine, push down on the inhaler once.
• Then, while breathing in through your lips, hold your breath for 10 seconds.
• Continue until you have taken the recommended amount of breaths, as advised by the doctor.
• After that, completely rinse your lips with water before spitting it out.

Side effects of Ticamet HFA 250 Inhaler

• Nausea
• Tremors
• Palpitations
• Headache
• Cough
• Vomiting
• Respiratory tract infection
• Fungal infection of the mouth
• Sore throat
• Hoarseness of voice
• Increased heart rate
• Nasopharyngitis (inflammation of the throat and nasal passages)
• Sinus inflammation
• Stomach discomfort
• Fungal infection of the oropharynx
• Musculoskeletal (bone, muscle, or joint) pain

Quick Suggestions:

• This medication must be inhaled only. You shouldn't swallow the pill.
• It should be consumed every day at the same hour.
• It takes time to start working, so it shouldn't be used to treat urgent respiratory issues. If you experience abrupt breathing trouble, use your rescue inhaler to stop it.
• Among the negative effects is possible to dry mouth. Regular mouthwash, improved oral hygiene, more water consumption, and sugarless confectionery may be beneficial.
• To prevent any fungal illnesses in your mouth and esophagus, gargle with tepid water after each inhalation.
• Take the first dosage of this medication under the guidance of a doctor because coughing or bronchospasm may occur right away after use.
• Because medications like Ticamet HFA 250 Inhelar and low oxygen levels in the blood (hypoxia) can reduce blood potassium levels, your doctor may check your potassium levels frequently.
• Ticamet HFA 250 Inhelar may only be taken in trace quantities into the blood after inhalation. As a result, negative adverse effects are rare.
• To relieve tension and lower your chance of having an asthma episode, try progressive muscle relaxation methods, deep breathing exercises, meditation, and frequent exercise.
• Quitting smoking may decrease the Seroflo 250 Inhaler 120 MDI's efficacy and aggravate a breathing issue that is already getting worse in the airways.
• You'll be able to fill and empty your airways with more oxygen if you learn breathing techniques.

Indications of Ticamet 250 HFA Inhaler

To manage and avoid respiratory conditions like asthma and chronic obstructive pulmonary disease, people use the Ticamet 250 HFA Inhaler 120 puffs. (COPD). Ticamet 250 HFA Inhaler enhances pulmonary function and successfully manages and avoids the deterioration of chronic bronchitis and emphysema (shortness of breath). (inflammation of the lining of your bronchial tubes). Salmeterol and Fluticasone propionate, the two medications that make up the Ticamet 250 HFA Inhaler 120 puffs, are used to treat COPD and the symptoms of asthma. (COPD). Salmeterol is a vasodilator, which means it relaxes muscles and opens up the passageways in the lungs. As a result, respiration becomes simpler. The corticosteroid drug family that includes fluticasone propionate prevents the production of specific molecules that trigger inflammatory responses by working on the inner cells of the nose lining. thereby bringing solace to the pain of sneezing, a runny or clogged nose, and sinuses.

Pharmacology

Salmeterol: Salmeterol is a selective long-acting (12-hour) β2 adrenergic receptor agonist with long side chains that bind to sites outside the receptor.

A long-acting selective 2 agonist called salmeterol xinafoate is used to treat asthma and other types of diffuse airway obstruction. A corticosteroid with primarily glucocorticoid activity is fluticasone propionate. At regular doses, fluticasone propionate is said to have a local effect on the lungs but no systemic effect.

Fluticasone propionate can enhance lung function and stop the progression of the disease, while salmeterol can prevent symptoms. For patients receiving both a corticosteroid and an inhaled -agonist simultaneously, the preparation may offer a more practical option. The following is a discussion of the two drugs' respective mechanisms of action

Dosage of Ticamet 250 HFA Inhaler 120 puffs

Inhalation Aerosol:

• Adults and teenagers For patients 12 years of age and older:  The recommended dosage is two puffs of 25 mg salmeterol and 50 mg fluticasone propionate, two puffs of 25 mg salmeterol and 125 mg fluticasone propionate, or two puffs of 25 mg salmeterol and 250 mg fluticasone propionate twice daily.
• Children (4–12 years): 2 puffs each twice daily each containing 25 g of salmeterol and 50 g of fluticasone propionate.

Inhalation Powder in Capsule (For Asthma):

• Salmeterol 50 mg & Fluticasone 100 mg or Salmeterol 50 mg & Fluticasone 250 mg twice daily for adults and adolescents (12 years and older) (morning and evening, approximately 12 hours apart).
• For patients 12 years of age and older, the starting doses of salmeterol 50 mg, fluticasone 100 mg, and salmeterol 50 mg, fluticasone 250 mg are based on the severity of the patient's asthma.
• The maximum dose that is advised is Fluticasone 500 mg twice daily and Salmeterol 50 mg.
• Salmeterol 50 mg & Fluticasone 100 mg twice daily are the recommended dosages for children (4–11 years old) with uncontrolled asthma who are not taking an inhaled corticosteroid (morning and evening, approximately 12 hours apart).

Inhalation Powder in Capsule (For COPD): 

• Salmeterol 50 µg & Fluticasone 250 µg twice daily (morning and evening, approximately 12 hours apart). Rinsing the mouth after each inhalation is advised.

Inhalation Powder in Maxhaler (For Asthma): 

This is a molded plastic device containing a foil strip with 60 regularly placed blisters containing pre-dispensed inhalation powder. Patients should be made aware that Maxhaler must be used daily for optimum benefit, even when asymptomatic.

Adults and Adolescents (12 years and older)-

• 50/100 Maxhaler: One Inhalation twice daily
• 50/250 Maxhaler: One Inhalation twice daily
• 50/500 Maxhaler: One Inhalation twice daily

Children (4 years and older)-

50/100 Maxhaler: 

• Twice each day, one inhalation. Fluticasone propionate delivered by this Maxhaler in children may not exceed the maximum licensed dose of 100 ugs twice daily. No information is available regarding the use of this Maxhaler in children under the age of four.

Inhalation Powder in Maxhaler (For COPD):

Maxhaler: 

• One Inhalation twice daily

Special patient groups: 

• There is no need to adjust the dose in elderly patients or in those with renal impairment. There are no data available for use of this in patients with hepatic impairment.

Using the Maxhaler: 

This tool is user-friendly for patients, ready to use, and simple to hold. Follow the usage guidelines when using.

Although using an inhaler seems straightforward, the majority of patients are unaware of the proper technique. Less medicine can enter the lungs if the inhaler is used incorrectly. Asthma attacks can be avoided or reduced in severity with proper and consistent use of the inhaler.

Administrations of Ticamet 250 HFA Inhaler 120 puffs

Following simple steps can help to use Inhaler effectively (According to "National Asthma Guidelines for Medical Practitioners" published by Asthma Association):

• Take off the cap.
• Shake the inhaler (at least six times) vigorously before each use.
• If the inhaler is new or if it has not been used for a week or more, shake it well and release one puff into the air to make sure that it works.
• Breathe out as fully as comfortably possible & hold the inhaler upright.
• Place the actuator into the mouth between the teeth and close the lips around the mouthpiece.
• While breathing deeply and slowly through the mouth, press down firmly and add fully to the canister to release medicine.
• Remove the inhaler from the mouth. Continue holding your breath for at least 10 seconds or as long as it is comfortable.
• If the doctor has prescribed more than one inhalation per treatment, wait 1 minute between puffs (inhalations). Shake the inhaler well and repeat steps 4 to 7.
• After use, replace the cap on the mouthpiece. After each treatment, rinse your mouth with water.
• Check your technique in front of a mirror from time to time, if you see a white mist during the inhalation, you may not have closed your lips properly around the mouthpiece, or you may not be breathing in as you press the can. This indicates a failure of the technique. If this happens, repeat the procedure from step 4 carefully.

Instructions for Cleaning Inhaler:

• At least once per week, clean your inhaler.
• Do not submerge the metal canister in water; instead, remove the canister and rinse the plastic actuator and cap in warm water.
• Replace the metal canister with the actuator with a gentle twist after thoroughly drying the actuator and cap.
• Attach the mouthpiece's cap.

Side Effects of Ticamet 250 HFA Inhaler 120 Puffs

Salmeterol and fluticasone propionate are both present in the preparation, so it is reasonable to anticipate the kind of side effects and their severity. After the two compounds were administered simultaneously, no further negative events happened. adverse reactions to fluticasone propionate or salmeterol are described below. 
Salmeterol: 

• Tremors, subjective palpitations, and headaches have been listed as pharmacological side effects of 2 receptor agonist therapy, but they are frequently transient and will go away with continued therapy. Arrhythmias, such as supraventricular tachycardia, extra contractions, and atrial fibrillation, can happen, usually in susceptible patients. reports of allergic reactions like rash, edema, and angioedema, as well as joint pain. Itching in the oropharynx has been reported. Muscle cramps have not been reported very often.

Fluticasone Propionate: 

• Some patients may experience candidiasis and hoarseness of the mouth and throat (thrush). Allergic skin reactions have been reported. There have been a few isolated reports of facial and oropharyngeal edema. Gargling with water after using the salmeterol/fluticasone propionate inhaler can reduce the likelihood of hoarseness and yeast infections.

Interactions

Selective and non-selective beta-blockers should be avoided by asthma patients unless necessary. Clinically significant drug interactions are not possible due to the very low plasma concentration that is attained after inhalation. Because systemic exposure to fluticasone propionate may be increased when known strong CYP3A4 inhibitors (such as ketoconazole and ritonavir) are used together, care should be taken.

Contraindications

It is contraindicated for patients with a history of allergy to any ingredient.

Pregnancy & Lactation

Only when the expected benefit to the mother exceeds any possible risk to the fetus or child should the use of drugs during pregnancy and breastfeeding be considered. There is an insufficient experience in the use of salmeterol xinafoate and fluticasone propionate during human pregnancy and lactation. There are no data on human breast milk.

Precautions & Warnings

• If there is an infection, additional corticosteroid treatment should be considered, including antibiotics.
• As with all inhaled corticosteroid-containing drugs, patients with active or inactive tuberculosis should use this preparation with caution.
• While using Ticamet HFA 250 Inhaler 120 puffs, it is advised to routinely check potassium levels as it may result in reduced potassium levels in the blood.
• Before using Ticamet HFA 250 Inhaler 120 puffs, let your doctor know if you have high blood pressure, diabetes, a chest or lung infection, hyperthyroidism (overactive thyroid), hypokalaemia (low potassium levels in the blood), cataracts, osteoporosis (weak bones), tuberculosis, problems with your heart, liver, or adrenal glands.

Storage Conditions

Pressurized canisters do not puncture, break or incinerate even when empty. Avoid storage in direct sunlight or heat. Store below 30°C. Keep away from eyes. Keep away from children.