Comet 850mg | 10pcs | Anti-Diabetic Medicine | ePharma
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Comet 850mg Tablet

Generic: Metformin Hydrochloride

Type: Tablet

Pack Size: 10 Pcs

Comet 850mg Tablet is an antidiabetic medicine that helps to control blood sugar in people with type 2 diabetes mellitus.


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Discount Price: ৳ 56.27
MRP: ৳ 60.5 7% Off

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Description:

Metformin is a medication belonging to the biguanide group, commonly prescribed to manage type 2 diabetes. It helps regulate elevated blood glucose levels in individuals with this condition. Type 2 diabetes is a chronic disorder characterized by impaired glucose processing in the body. People with type 2 diabetes either do not produce enough insulin or have insulin resistance, where the body's insulin does not function effectively. This form of diabetes is often associated with middle-aged or older individuals and is sometimes referred to as adult-onset diabetes.

Metformin is typically recommended when dietary changes and exercise alone are insufficient to control blood sugar levels in individuals with type 2 diabetes. It is considered the first-line therapy for managing this condition. Metformin works by enhancing the body's responsiveness to insulin, reducing the liver's production of glucose, and delaying the absorption of sugar in the stomach and intestines. Additionally, Metformin has off-label uses in treating women with polycystic ovary syndrome (PCOS), where it helps regulate menstrual cycles, balance hormones, lower blood sugar levels, and promote ovulation.

In general, Metformin has a low likelihood of causing significant side effects. Common side effects may include diarrhea, nausea, vomiting, or a metallic taste in the mouth. Lactic acidosis, a rare condition characterized by elevated lactic acid levels in the body, can occur in very rare cases and may present with symptoms like dizziness, drowsiness, and muscle pain. It's important to promptly seek medical attention if any of these symptoms arise.

To optimize the effectiveness of Metformin, it should be used in conjunction with a healthy lifestyle. This includes weight management, especially if one is overweight (BMI >25), a reduced-calorie diet (low in fat and sugar), and increased physical activity (at least 150 minutes of exercise per week). Discuss any medical conditions or concerns with your doctor to ensure safe and effective use of Metformin.

Safety Advices


Alcohol
UNSAFE

Avoid alcohol while taking Comet 850mg Tablet to prevent the risk of lactic acidosis, which can lead to unpleasant side effects.


Pregnancy
CONSULT YOUR DOCTOR

Comet 850mg Tablet is generally not recommended during pregnancy. However, your doctor may prescribe it if they believe the benefits outweigh the risks. Do not take Comet 850mg Tablet during pregnancy without your doctor's advice.


Breastfeeding
CONSULT YOUR DOCTOR

Comet 850mg Tablet is not recommended if you are breastfeeding or planning to breastfeed your baby.


Driving
CAUTION

Comet 850mg Tablet, when used as monotherapy, does not cause hypoglycemia (low blood sugar) and therefore does not affect your ability to drive or operate machinery.


Kidney
CONSULT YOUR DOCTOR

Use Comet 850mg Tablet cautiously, especially if you have a history of kidney diseases or conditions. Your doctor may adjust your dose based on your renal functions. METFORMIN is not recommended in cases of severe kidney disease. Regular monitoring of kidney function tests is important if you are taking Comet 850mg Tablet.


Liver
CONSULT YOUR DOCTOR

Take Comet 850mg Tablet with caution, especially if you have a history of liver diseases or conditions. Your doctor may need to adjust your dose accordingly.

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Uses:
How does
Side Effects of Comet 850mg Tablet

Common side effects include gastrointestinal symptoms like nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. Rare side effects may involve hematological, metabolic, nervous system, gastrointestinal, hepatobiliary, and skin and subcutaneous tissue disorders. These side effects should be promptly reported.

Quick Suggestions:
  • While Metformin itself has a lower risk of causing low blood sugar (hypoglycemia), this risk can increase when it's used in combination with other antidiabetic medications, alcohol, or if meals are delayed or skipped. It's a good idea to carry a quick sugar source with you for immediate relief in case of low blood sugar.
  • Although rare, Metformin can potentially lead to a serious condition called lactic acidosis, characterized by symptoms like deep or rapid breathing, persistent nausea, vomiting, and stomach pain. If you experience any of these symptoms, contact your doctor immediately.
  • Prolonged use of Metformin may result in vitamin B12 deficiency, leading to conditions such as anemia. Symptoms of vitamin B12 deficiency can include fatigue, pale skin, shortness of breath, or headaches. If you notice any of these symptoms, inform your doctor as you may require vitamin B12 supplements.
  • Your doctor will regularly monitor your blood sugar levels and kidney function while you're on Metformin to ensure it's effectively managing your diabetes and not causing any adverse effects.
Indications:

Comet 850 (Metformin Hydrochloride tablet) is prescribed as an adjunct to diet and exercise to enhance glycemic control in both children and adults with type 2 diabetes mellitus.

Comet TM XR (Metformin Hydrochloride extended-release tablet) is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Pharmacology:

Metformin, an antihyperglycemic agent, enhances glucose tolerance in type 2 diabetes patients. It reduces both basal and postprandial plasma glucose levels. Metformin achieves this by decreasing hepatic glucose production, reducing intestinal glucose absorption, and increasing peripheral glucose uptake and utilization. Importantly, it does not cause hypoglycemia and does not induce hyperinsulinemia, distinguishing it from sulfonylureas.

Dosage & Administration of Comet 850mg Tablet

The dosages of Comet 850 and Comet TM XR should be tailored to individual effectiveness and tolerance, with careful consideration of maximum daily doses.

  • The maximum daily dose of Comet TM is 2550 mg for adults and 2000 mg for pediatric patients aged 10-16 years.
  • The maximum daily dose of Comet TM XR for adults is 2000 mg.
  • Comet TM should be taken with meals in divided doses, while Comet TM XR is generally administered once daily with the evening meal. Comet TM XR tablets must be swallowed whole, not crushed or chewed.
  • Initiate treatment with low doses, gradually increasing them to reduce gastrointestinal side effects and identify the minimum effective dose for glycemic control.
Interaction
  • Chronic co-administration of Metformin and furosemide has no known interactions.
  • Nifedipine may enhance Metformin absorption.
  • Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin) eliminated by renal tubular secretion could potentially interact with Metformin by competing for renal tubular transport systems.
  • Metformin has no significant effect on cimetidine pharmacokinetics.
  • Certain drugs, such as thiazides, diuretics, corticosteroids, phenothiazines, and others, may induce hyperglycemia and disrupt glycemic control.
Contraindications

Comet 850mg Tablet should not be used in patients with:

  1. Renal disease or dysfunction (e.g., indicated by serum creatinine levels > 1.5 mg/dL [males], > 1.4 mg/dL [females], or abnormal creatinine clearance).
  2. Known hypersensitivity to metformin hydrochloride.
  3. Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.
Pregnancy & Lactation

Metformin falls under the Pregnancy Category B. Insulin is typically recommended during pregnancy to maintain near-normal blood glucose levels. Both Metformin immediate and extended-release tablets should only be used during pregnancy if deemed necessary by a healthcare provider.

Precautions & Warnings

Metformin is primarily excreted through the kidneys, and the risk of accumulation and lactic acidosis increases with renal function impairment. Patients with elevated serum creatinine levels for their age should not receive Metformin. In elderly patients, Metformin should be titrated carefully to establish the minimum effective dose due to age-related reduced renal function.

Storage Conditions

Store in a cool, dry place away from light and out of children's reach.

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Check our pricing section for Comet 850mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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