Xyotil 40mg - ePharma
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Xyotil 40mg

Generic: Olmesartan

Type: Tablet

Pack Size: 10s pack

Tablet, Generic Name: Olmesartan 40mg, Manufacturer: Incepta Pharmaceuticals Ltd.


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Discount Price: ৳ 139.5
MRP: ৳ 150 7% Off

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Description:

Indications

Olmesartan Medoxomil is used to treat high blood pressure. It can be used either alone or in conjunction with other antihypertensive medications.

 

Pharmacology

Angiotensin-II is a strong vasoconstrictor, the major vasoactive hormone of the renin-angiotensin system, and a key component in the pathophysiology of hypertension. It is produced from angiotensin-I in a process catalyzed by the angiotensin-converting enzyme (ACE). It also increases the adrenal cortex's production of aldosterone. Olmesartan inhibits angiotensin-vasoconstrictor II's and aldosterone-secreting actions by specifically inhibiting angiotensin-II binding to the AT 1 receptor, which is present in numerous tissues (e.g. vascular smooth muscle, adrenal gland). Olmesartan is a reversible and competitive inhibitor of the AT 1 receptor, according to in-vitro binding tests. Olmesartan has no effect on ACE (kinase-I, the enzyme that converts angiotensin-I to angiotensin-II and degrades bradykinin).

 

Dosage & Administration

Dosage must be individualized. The usual recommended starting dose of Olmesartan is 20 mg once daily when used as monotherapy in patients who are not volume-contracted. For patients requiring further reduction in blood pressure after 2 weeks of therapy, the dose of Olmesartan may be increased to 40 mg. Doses above 40 mg do not appear to have a greater effect. Twice-daily dosing offers no advantage over the same total dose given once daily.

No initial dosage adjustment is recommended for elderly patients, for patients with moderate to marked renal impairment (creatinine clearance <40 ml/min) or with moderate to marked hepatic dysfunction. For patients with possible depletion of intravascular volume (e.g. patients treated with diuretics, particularly those with impaired renal function), Olmesartan should be initiated under close medical supervision and consideration should be given to use of a lower starting dose. Olmesartan may be administered with or without food.

 

Interaction

When Olmesartan was co-administered with other medications, no major drug interactions were found.

With regard to food and others: Food has no effect on the bioavailability of Olmesartan.

 

Contraindications

Olmesartan is not recommended for people who are allergic to any of the product's components.

 

Side Effects

Back discomfort, bronchitis, elevated creatine phosphokinase, diarrhea, headache, hematuria, hyperglycemia, hypertriglyceridemia, influenza-like symptoms, pharyngitis, rhinitis, and sinusitis are the most frequent adverse effects.

Chest discomfort, peripheral edema, and arthritis are uncommon.

 

Pregnancy & Lactation

Pregnancy: If you are pregnant, stop using this product as soon as possible. Drugs that operate directly on the renin-angiotensin system can cause damage and even death to the growing baby when taken during the second and third trimesters of pregnancy.

Nursing Mothers: It is unknown if Olmesartan is excreted in human milk, however it is released in low concentrations in nursing rats' milk. Because of the risk of harmful effects on the nursing child, a choice should be taken whether to cease breastfeeding or the medicine, taking into consideration the drug's value to the mother.

 

Precautions & Warnings

Changes in renal function may be expected in susceptible people treated with olmesartan medoxomil as a result of suppressing the renin-angiotensin-aldosterone pathway. Treatment with angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists has been associated with oliguria and/or progressive azotemia, as well as (rarely) acute renal failure and/or death in patients whose renal function may be dependent on the activity of the renin-angiotensin-aldosterone system (e.g., patients with severe congestive heart failure). Patients receiving olmesartan medoxomil may experience similar outcomes.

Storage Conditions

Store in a cool, dry location below 30ºC, away from light and moisture. Keep out of children's reach.

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Check our pricing section for Xyotil 40mg price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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