Xenovate 0.05% Ointment

Uses of Xenovate 0.05% Ointment

• Corticosteroid-responsive Dermatoses
• Psoriasis
• Scalp Psoriasis
• Plaque-type Psoriasis
• Vitiligo
• Eczema
• Alopecia areata
• Herpes labialis
• Lichen sclerosis
• Lichen
• Mycosis fungoides
• Corticosteroid-responsive dermatoses

How does Xenovate 0.05% Ointment work?

Xenovate 0.05% Ointment is an antifungal medicine that works by damaging the cell membrane (protective covering) of the fungi. This prevents the growth of fungi and stops the spread of infection.

Side Effects of Xenovate 0.05% Ointment

• Burning or stinging sensation
• Pain (application site)
• Irritation or itching
• Skin thinning may cause stretch marks
• Blood vessels under the surface of your skin may become more noticeable.

Quick Suggestions:

• Xenovate 0.05% Ointment is meant for external application and should not be ingested.
• Wash your hands before and after using this medicine unless your hands are to be treated.
• Do not use more than the prescribed amount of this medicine or do not use it for longer periods of time than recommended by your doctor.
• Before using Xenovate 0.05% Ointment, please discuss with your doctor if you have any other skin conditions.
• If you experience any side effects after using this medicine, talk to your doctor.
• Do not give this medicine to anyone else, even if they have the same condition as you do.

Indication of Xenovate 0.05% Ointment

• Treats fungal skin infections (such as ringworm, athlete’s feet, fungal nappy rash, and sweat rash)
• Relieves irritation of the vulva or at the end of the penis (which may be associated with thrush)

Pharmacology

Clobetasol Propionate is a topical corticosteroid with a high potency. It works as an anti-inflammatory, anti-pruritic, and vasoconstrictor. It inhibits late-phase allergic responses by exhibiting anti-inflammatory effects through several pathways. Mast cell density, chemotaxis, and eosinophil activation are all reduced. It also inhibits arachidonic acid metabolism and decreases cytokine production.

Dosage & Administration of Xenovate 0.05% Ointment

Adult Dose: For corticosteroid-responsive skin conditions: Apply a thin layer to affected areas every 12 hours, gently rubbing it in completely. Do not exceed 50 g per week. For scalp psoriasis: Apply a thin film to the dry scalp once a day. Leave it on for 15 minutes, then add water, lather, and rinse thoroughly. For moderate to severe plaque-type psoriasis: Apply to the affected scalp area every 12 hours for up to 2 weeks, if the affected area is less than 10% of the body surface area. Do not exceed 50 g per week.

Child Dose: Below 12 years: Safety and efficacy not established 12 years and above Follow the same instructions as adults.

Instructions for Use: Always use Xenovate 0.05% Ointment as directed by your physician. It is meant for external use only. Clean and dry the affected area before applying the medicine. Gently apply a thin layer to the affected area and rub it in. Wash your hands before and after applying the medicine. Avoid using Xenovate 0.05% Ointment on your face, eyes, or large areas. Do not use it under bandages or for an extended period without consulting your doctor. Your doctor will determine the application duration and frequency based on the type of infection.

Interaction

• Possible interactions with HIV medication (e.g., ritonavir) and antifungal medication (e.g., itraconazole).
• No known interactions with food.

Caution advised in patients with:

• Diabetes
• Eye problems
• Skin infections
• Adrenal gland problems

Contraindications

• Not suitable for children under 12 years old. Long-term use for ulcers, rosacea, and itching should be avoided.
• Contraindicated in conditions like rosacea, acne vulgaris, perioral dermatitis, primary cutaneous viral infections (e.g., herpes simplex, chickenpox), and hypersensitivity to the product.
• The scalp application is not to be used for scalp infections.

Pregnancy & Lactation

Pregnancy: Safety data on clobetasol in pregnant women is not available. Published data indicate a significantly increased risk of low birth weight when using more than 300 grams of potent or very potent topical corticosteroid during pregnancy. Pregnant women should be informed of the potential risk to the fetus and should use clobetasol on the smallest skin area and for the shortest duration possible.

Lactation: There is no information available about the presence of clobetasol in breast milk or its effects on breastfed infants or milk production. Systemically administered corticosteroids can appear in human milk and potentially affect growth or endogenous corticosteroid production. The extent of systemic absorption from topical clobetasol and its presence in human milk is unknown. To minimize exposure to the breastfed infant, use clobetasol on the smallest skin area and for the shortest duration possible while breastfeeding. Breastfeeding women should avoid applying clobetasol directly to the nipple and areola to prevent direct infant exposure.

Precautions & Warnings

• Xenovate 0.05% Ointment may not be suitable for everyone. Inform a healthcare professional before using this medicine if you have ever had an allergic reaction to Clobetasol Propionate, any components in Xenovate 0.05% Ointment or any other medication. In case of overdose, cleanse the area thoroughly and reapply the medicine.
• When applying the medication around the eyes or on the eyelids, exercise caution as repeated contact with the eyes could lead to cataracts or glaucoma. Avoid using Xenovate 0.05% Ointment concurrently with other creams or ointments, such as moisturizers. Allow a minimum of 30 minutes between applying Xenovate 0.05% Ointment and any other product.
• Xenovate 0.05% Ointment is not intended for use in treating conditions such as acne, rosacea, perioral dermatitis, anogenital pruritus, itchy, broken, or infected skin that is not inflamed, and widespread plaque psoriasis (except single lesions).
• Consult a doctor before using this medication if you are attempting to conceive, are already pregnant, or are breastfeeding. The appropriate dose for children depends on their age and can be advised by a doctor or pharmacist.

Storage Conditions

Store Xenovate 0.05% Ointment at room temperature, and keep away from direct sunlight. Keep away from pets and children.