Xenole 500mg 10pcs - ePharma
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Xenole 500mg 10pcs

Generic Name: Esomeprazole 20 mg + Naproxen 500 mg 

Manufacturer/Distributor: Square Pharmaceuticals Ltd. 


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Discount Price: ৳ 139.5
MRP: ৳ 150 7% Off

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Description:

Indications

A combination drug that aids in pain relief is Xenole 500. It is used to treat rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis pain and inflammation. It can also be used to treat toothaches, ear and throat pain, back pain, and muscle pain.

Pharmacology

This consists of a Naproxen core with an enteric coating and a magnesium esomeprazole instant-release coating. Esomeprazole is consequently released into the stomach first, and then Naproxen dissolves in the small intestine.

A nonsteroidal anti-inflammatory drug (NSAID) called naproxen has analgesic and antipyretic properties. Prostaglandin production is suppressed by naproxen, which is how it works. Proton pump inhibitors like esomeprazole prevent the production of stomach acid by specifically inhibiting the H+/k+ -ATPase in the gastric parietal cell. Esomeprazole inhibits the final stage of acid production by specifically targeting the proton pump; as a result, stomach acidity is decreased.

Dosage  

Before choosing to use this tablet, carefully weigh the benefits, risks, and alternative treatment options. Utilize the shortest possible duration and lowest effective dose in accordance with each patient's unique treatment objectives. A different course of treatment should be taken into consideration if an Esomeprazole dose less than the recommended daily maximum of 40 mg is more effective.

Osteoarthritis, ankylosing spondylitis, and rheumatoid arthritis

  • Adults should take one tablet twice daily that contains either 375 mg of naproxen or 500 mg of naproxen and 20 mg of esomeprazole.
  • Those 12 years of age and older who are adolescents who have juvenile idiopathic arthritis
  • If you weigh more than 50 kg, take 375 mg of naproxen and 20 mg of esomeprazole, or 500 mg.

Administration

  • The pill should not be broken, chewed, crushed, or dissolved. 
  • This pill should be taken 30 minutes before meals.

Interaction

When it comes to medicine:

The use of NSAIDs concurrently may decrease the antihypertensive impact of ACE inhibitors, diuretics, and beta-blockers.

Concurrent use of this pill with warfarin may raise the risk of a bleeding problem.

Esomeprazole reduces stomach acid secretion and may interfere with medication absorption in cases where gastric pH is a significant factor of bioavailability (eg. Ketoconazole, iron salts, and digoxin).

With food and others: Administration of Naproxen and Esomeprazole along with high-fat meal has no effect on naproxen absorption but considerably prolongs Tmax by 10 hours and reduces peak plasma concentration (Cmax) by around 12% in healthy individuals.

Contraindications

  • any previously known hypersensitivity to the ingredients or substituted benzimidazoles in this tablet.
  • In the past, aspirin or other NSAIDs have triggered allergic-like reactions like asthmatic urticaria.
  • Use during the peri-operative stage of coronary artery bypass graft (CABG) surgery.

Side Effects

  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Indigestion
  • Flatulence
  • Stomach pain
  • Flu-like symptoms

Pregnancy & Lactation

C is the pregnancy category. It should be avoided in late pregnancy since it may cause premature closure of the ductus arteriosus. Because of the Naproxen component, this tablet should not be taken by nursing mothers.

Precautions & Warnings

Patients who have a history of CV disease or risk factors may be at a higher risk. In patients with fluid retention or heart failure, this pill should be taken with care.

Storage Conditions

Store at temperatures below 30°C and keep away from light and moisture. Keep out of children's reach.

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Check our pricing section for Xenole 500mg 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.
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