Trocer Spray

Indications

Nitroglycerin spray is indicated for acute relief of an attack or prophylaxis of angina pectoris due to acute left ventricular failure or coronary artery disease.

Uses of Trocer Spray

• Angina (heart-related chest pain)

Pharmacology

Nitroglycerin's main pharmacological function is to relax vascular smooth muscle, resulting in a vasodilator effect on both peripheral arteries and veins, with the latter having a stronger effect. The dilation of post-capillary arteries, such as big veins, promotes peripheral blood pooling and reduces venous return to the heart, lowering left ventricular end-diastolic pressure (pre-load). Arteriolar relaxation lowers arterial pressure and lowers systemic vascular resistance (after-load).

Dosage & Administration

At the onset of an attack, 1 or 2 metered sprays should be administered under the tongue. No more than 3 metered sprays are recommended within a 15 minute period. If the chest pain persists, prompt medical attention is recommended. Nitroglycerin spray may be used prophylactically 5 to 10 minutes prior to engaging in activities which might precipitate an acute attack.

Interaction

May cause severe hypotension when used along with antihypertensives, tricyclic antidepressants.

Contraindications

Hypersensitivity to nitrates or any other formulation component. Hypertrophic obstructive cardiomyopathy causes hypotension, hypovolemia, severe anemia, cerebral haemorrhage and brain damage, mitral stenosis, and angina. Phosphodiesterase inhibitors for the treatment of erectile dysfunction are given at the same time.

Side Effects

A number of nitrate related adverse effects may occur like, burning sensation in the mouth, headache, facial flashing, dizziness, nausea, vomiting, sweating , palpitation, sensation of heat, postural hypotension and reflex tachycardia.

Pregnancy & Lactation

There is no evidence relating to the safety of nitrates in pregnancy and lactation. Therefore, Nitroglycerin Spray may be used in pregnancy and lactation only when considered essential by the physician.

Precautions & Warnings

Severely impaired renal or hepatic function, Hypothyroidism , Malnutrition or hypothermia.

Therapeutic Class

Nitrates: Coronary vasodilators

Storage Conditions

Keep away from light and heat in a cool, dry area. All drugs should be kept out of the reach of youngsters.