Rozith 500mg Tablet 6Pcs

Uses of Rozith

• Treatment of Bacterial infections

How Rozith works

Rozith is an antibiotic. It works by preventing the synthesis of essential proteins required by bacteria to carry out vital functions. Thus, it stops the bacteria from growing and prevents the infection from spreading.

Side effects of Rozith

• Vomiting
• NauseaNausea and Vomiting
• Chest pain
• Dizziness
• Fatigue
• Headache
• Rash
• Excessive gas in the stomach
• Photosensitivity of skin
• Abdominal pain
• Diarrhea

Quick Suggestions:

• Even if you feel better, do not miss any doses and complete the whole course of therapy. If you stop it too soon, the infection can return and be more difficult to cure.
• Take Rozith 500mg Tablet two hours before or after a meal.
• Avoid drinking alcohol while taking Rozith 500mg Tablet since it might dehydrate you and interfere with your sleep. Your body may find it more difficult to support the Rozith 500mg Tablet in fighting off infections as a result.
• Antacids should not be consumed before or after taking Rozith for 2 hours.
• The optimum time to take probiotics is after finishing the entire course of Rozith 500mg Tablet in order to replenish any good bacteria that may have been lost in the gut. The chance of antibiotic-associated diarrhea can be decreased by taking probiotics after receiving antibiotic therapy.
• The adverse effect of diarrhea is possible, but it should go away once your treatment is finished. If it doesn't cease or if you notice blood in your feces, call your doctor.
• If you get an itchy rash, swelling of the face, throat, or tongue, or breathing problems while using Rozith, stop taking it right away and tell your doctor.

Indication

Rozith  Tablet contains Azithromycin which belongs to the group of medicines called Macrolide antibiotics. It is used-

• Treats mild to moderate susceptible infections caused by bacteria and other micro-organisms which include chest, throat, and nasal infections such as bronchitis, pneumonia, tonsillitis, sore throat, and sinusitis.
• Treats ear infections as well as skin and soft tissue infections (such as abscesses and boils) in those who are afflicted.
• Treats those who have contracted sexually transmitted illnesses like cervicitis, which is brought by bacteria like Chlamydia trachomatis and Neisseria gonorrhea.

Pharmacology

Since azithromycin is acid-stable, it can be taken orally without concern for stomach acid. It takes time to digest; on a cleansed stomach, its retention is more pronounced. For the verbal form, the adult peak development time ranges from 2.1 to 3.2 hours. Azithromycin is effectively transported to the site of contamination because of the high concentration in phagocytic cells. Extremely high azithromycin concentrations are excreted during active phagocytosis. Azithromycin concentrations in tissue can be up to 50 times higher than those in plasma. The high particle uptake and lipid clearance may be the cause of this.

Azithromycin's long half-life enables prolonged administration of a single dose while keeping bacteriostatic levels in infected tissues for a number of days. Azithromycin plasma concentrations decreased polyphonically after a single 500 mg measurement, with a plasma clearance of 630 ml/min and a terminal half-life of 68 hours. The extensive absorption and subsequent tissue clearance are thought to be the causes of the delayed terminal half-life. A major mode of elimination for azithromycin might be the nearly unchanged biliary excretion. Approximately 6% of the administered doses appeared in the urine as an unchanged drug after a week.

Microbiology: Azithromycin effectively affects the 50S ribosomal subunit of susceptible microorganisms and, as a result, interacts with a variety of microbial proteins through interferometry. Mixtures of corrosive nucleic acids are unaffected. It has been demonstrated that azithromycin is resistant to the majority of microorganism absorption limits, both in vitro and during a clinical infection:

Gram-positive bacteria are extremely active and easy to culture: Microorganisms include Streptococcus aureus, Streptococcus pneumonia, Streptococcus agalactiae, and Streptococcus pyogenes facultative. Neisseria gonorrhoeae, Haemophilus ducreyi, Moraxella catarrhalis, and Haemophilus influenzae

It is not anticipated that other microorganisms, such as Chlamydia pneumoniae, Chlamydia trachomatis, or the production of beta-pneumonia lactamases, will have an impact on the production of beta-active azithromycin.

Microbes that are aerobic and gram-positive include streptococci (C, F, and G beams) and streptococcus viridans. Gram-negative bacteria that are aerobic and simple to culture: Legionella pneumophila and Bordetella pertussis

Anaerobic microorganisms: Prevotella Livia and Peptostreptococcus species

Dosage of Rozith 500mg Tablet

Oral- 

Adult: 

• Orally take 500 mg once daily for 3 days, or take 250 mg once on days 2 through 5 for 4 days after taking 500 mg once on day 1.
• The dosage for Chlamydia trachomatis-related sexually transmitted diseases in adults is 1 gm given as a single dose, or 500 mg once on day 1 followed by 250 mg once daily for the next 2 days may also be given.

Children: 

• 10 mg/kg body weight once daily for three days for kids older than six months
• If your body weight is between 15 and 25 kg, take 200 mg every day for three days.
• If your body weight is 26–35 kg, take 300 mg (112 teaspoonfuls) for three days; if it is 36–45 kg, take 400 mg (2 teaspoonfuls) for three days.
• Typhoid fever is treated with 500 mg (212 teaspoonfuls) once daily for 7–10 days.

Administration of Rozith 500mg Tablet

• Follow your doctor's instructions for this medication's dosage and duration.
• Take it all in at once. Don't chew it, break it, or crush it.
• Although Rozith can be taken with or without food, it is best to take it at a set time.

Interaction

Increases the levels of hexobarbital, terfenadine, digoxin, ciclosporin, and phenytoin in the blood. reduced rate of absorption when using antacids with magnesium and aluminum. elevated danger of ergot toxicity. Possible Fatal: Pimozide increases the risk of cardiotoxicity.

Contraindications

Patients who are extremely sensitive to azithromycin or any other macrolide antibiotic should not take azithromycin. It is not recommended to administer azithromycin and ergot derivatives simultaneously. Patients with hepatic illnesses should not take azithromycin.

Pregnancy & Lactation

The pregnancy Category of Azithromycin is B. Creature propagation ponders have illustrated that Azithromycin has no proof of hurt to the hatchling. There are no satisfactory and well-controlled considerations in pregnant ladies. Since creature generation thinks are not continuously prescient of human reaction, Azithromycin ought to be utilized amid pregnancy as it were in case satisfactory choices are not accessible. It isn't known whether Azithromycin is emitted in the breast drain. So, caution ought to be worked out when Azithromycin is managed by nursing ladies.

Precautions & Warnings

• Inform your physician if you have an electrolyte imbalance, myasthenia gravis, arrhythmia, or liver or muscular issues (jaundice). (low potassium or magnesium level).
• If you get watery or bloody diarrhea, stop taking Rozith 500mg Tablet and consult your doctor.
• The usage of Rozith 500mg Tablet may, in rare circumstances, induce diarrhea.
• However, wait until your doctor instructs you before taking any anti-diarrhea medication.
• It is uncertain if Rozith 500mg Tablet hurt the fetus while a woman is pregnant.
• Before using Rozith 500mg Tablet, check with your doctor if you are pregnant, expecting to become pregnant, or nursing a baby.
• If you have a macrolide antibiotic allergy, avoid using Rozith 500mg Tablet.
• If you use medication to decrease your cholesterol, let your doctor know. (statins like simvastatin, lovastatin, etc.), Colchicine and other anti-gout or anti-arthritis medications as well as overactive bladder medications (tolterodine).
• Patients with pneumonia who are deemed unsuitable for oral treatment due to moderate to severe sickness or risk factors should not use Rozith 500mg Tablet.

Storage Conditions

Keep in a dry put absent from light and warm. Keep out of the reach of children.