Rosen 28-Birth Spacing Tablet (Box)

Uses of Rosen 28

• Prevent pregnancy in women

How Rosen 28 Tablet works?

Rosen 28 ( Ethinylestradiol 0.03mg + Drospirenone 3mg) works by inhibiting the release of gonadotrophic hormones, which are responsible for initiating ovulation (the release of a mature egg from the ovaries) and ensuring the fertilized egg's effective implantation. They also decrease the thickness of the uterine lining, making it unsuitable for the fetus to implant and develop. They can also change the viscosity of the cervical mucous, making it difficult for the sperm to penetrate the cervix and fertilize the embryo. As a consequence, they make it difficult to have a healthy pregnancy.

Side Effects of Rosen 28

• Headache
• Dizziness
• Loss of consciousness
• Anxiety
• Vaginal bleeding
• Nausea
• Vomiting
• Diarrhoea
• Abdominal pain and discomfort
• Breast pain and tenderness
• Weight gain
• Depression
• Irregular menstrual periods
• Flu-like symptoms
• Swelling of face, lips, eyelids, tongue, hands, and feet
• Troubled breathing

Quick Suggestions:

• Rosen 28 Tablet has been recommended by your doctor to assist you in preventing conception.
• It also causes milder, less painful, and more frequent menstruation.
• It could help lower the chance of ovarian cancer.
• To help you recall to take your tablet, take it at the same time every day.
• Menstrual irregularities, such as spotting or blood between periods, or skipped periods, are possible. If this continues, see your doctor.
• If you are heavy, over the age of 35, smoke, are on extended bed rest, or have a history of blood clots, do not take Rosen 28 Tablet.
• If you observe unexplained swelling and pain in your extremities, shortness of breath, chest pain, intense headache, or changes in eyesight, stop taking this medication and contact your doctor right away.

Indications of Rosen 28

• Rosen 28 Tablet is a contraceptive pill that prevents pregnancy in a variety of methods.
• For starters, it stops an embryo from being expelled from your ovaries.
• Second, it thickens the fluid (mucus) in your cervix, making it more difficult for sperm to reach the egg.
• Furthermore, it stops the lining of your womb from thickening, making it unsuitable for the growth of an embryo.
• If used properly, Rosen 28 Tablet is a reliable and secure means of contraception.
• It does not interfere with sex, and you can go about your usual schedule without worry.
• To get the most out of it, follow the doctor's instructions.

Pharmacology

This is an oral contraceptive tablet containing both the synthetic progestin drospirenone and the synthetic estrogen ethinyl estradiol. This tablet's contraceptive impact is dependent on the interplay of several variables, the most significant of which are ovulation inhibition and changes in cervical secretions. If the tablet is taken as directed, it will prevent the eggs from developing to the point where they can be fertilized, and the cervical mucous will stay viscous, creating a sperm barrier and preventing the endometrium from accepting implantation. The estrogen/progestin combo has several beneficial qualities aside from stopping pregnancy. It can be used to identify contraceptive techniques, in addition to their bad qualities. Periods are more frequent, menstruation is less unpleasant, and blood is lighter. 

Drospirenone has anti-mineralocorticoid action and can prevent estrogen-induced sodium retention. Drospirenone has a positive lipid profile when combined with ethinyl estradiol, with a rise in HDL high-density lipoproteins. Drospirenone has antiandrogenic action but has no effect on the rise in ethinyl estradiol-related sex hormone binding globulin (SHBG), which can bind and inactivate endogenous androgens. Drospirenone lacks testosterone, estrogen, glucocorticoid, and anti-glucocorticoid action. When coupled with anti-mineralocorticoid and anti-androgenic qualities, drospirenone has biochemical and pharmacological properties that are very comparable to the endogenous hormone progesterone.

Dosage of Rosen 28

Adult Dosage: 

• 1 active tablet (3 mg drospirenone/0.03 mg EE) PO every day for 21 days for Contraception
• Then 1 inactive tablet PO every day for 7 days and 1 active tablet (3 mg drospirenone/0.02 mg EE) PO every 24 hours for 24 days
• Then 1 inactive tablet PO every 4 days Dysphoric Premenstrual Syndrome Premenstrual dysphoric disorder (PMDD) symptoms, but only if oral contraception is used for birth control.
• 1 active tablet (3 mg drospirenone/0.02 mg EE) PO every 24 hours for 24 days
• Then 1 inactive tablet PO every 4 days Avoid use if you have a liver condition.

Dose for Children

14 years of contraception: 

• Safety and effectiveness unknown >14-year-olds receive the same dose as adults.

The Renal Dose

• CrCl (ml/min) 50 CrCl (ml/min) 50 CrCl (ml/min) 50 CrCl ( Avoid using it.

Take Rosen 28 precisely as prescribed by your doctor. Rosen 28 should be taken with a drink of water. Do not eat or pulverize the medication. Rosen 28 can be used with or without food. Take Rosen 28 at the same hour every day if possible.

• Do not miss any Rosen 28 doses between treatments as this may decrease its efficacy. If you skip a dose of Rosen 28, take it as soon as you recall.
• To adjust for a skipped dosage, do not take a double quantity of Rosen 28 as this may result in bleeding or spotting.
• Your doctor will determine the appropriate dosage and length of treatment for you based on your age, body weight, and medical condition.

Administrations of Rosen 28

When to consume the tablets and how to ingest them:

• This tablet box includes 21 tablets. Each pill is labeled on the package with the day of the week it should be consumed. Take your pill around the same time every day, with some water if required. Continue in the direction of the lines until all 21 pills have been consumed. Take no tablets for the next 7 days. Menstruation (the withdrawal bleed) should commence during these 7 days; rarely, it will begin on days 2-3 after the last tablet. Even if your menstruation persists, begin taking your next pack on the eighth day. This means you'll always start fresh packets on the same day of the week, and your withdrawal bleed will occur on roughly the same days each month.

Starting your first pack of this tablet: 

• If you haven't used a hormonal control in the previous month. On the first day of your period, or the first day of menstrual bleeding, start consuming this pill. Take a notepad that has that weekday written on it. Take a pill with the label Sunday, for instance, if your menstruation begins on a Sunday. the days in that sequence, then. You may also begin between days 2 and 5 of your cycle, but in that case, you must also use a second means of contraception (the barrier technique) for the first seven days of the first cycle of taking the tablets.

After switching to another combination pill: 

• The day following the day you finish the last tablet from your current Pillbox, you can begin consuming this tablet. (this means no tablet-free break). You can begin taking this medication the day after the first active tablet if your current pill package also includes inert pills. (if you are not sure which this is, ask your doctor or pharmacist). You can begin later, but never later than the day after your current medication's pill break. (or the day after the last inactive tablet of your present Pill).

When switching from a progestogen-only (Mini Pill) pill: 

• You can cease taking the mini-pill at any moment and begin taking this tablet at the same time the following day. But make sure you also use a second method of contraception (a barrier technique) for the first seven days after starting the medication.

When switching from an injectable or implant: 

• Begin taking this pill on the day your device is removed or when your next injection is scheduled. But for the first seven days after taking the tablet, make sure you also use a second means of contraception (a barrier technique).

After giving Birth: 

• If you've just given birth, your doctor might advise you to delay to start taking this medication until after your first regular menstruation. It is occasionally feasible to begin sooner. You'll get advice from your specialist. You should first talk to your doctor about taking this pill if you are breastfeeding.

After a miscarriage or an Abortion: 

• Your doctor will advise you.

When this pill is consumed in excess (overdose):

• Too many tablet pills taken at once have not been linked to any severe negative effects. When taking multiple pills at once, you run the risk of experiencing sickness, vomiting, or vaginal hemorrhaging. Ask your doctor for guidance if you learn that a kid has taken this medication.

When to stop taking this Pill: 

• You are free to stop taking this tablet whenever you like. Ask your doctor about other birth control options if you don't want to get pregnant. It is typically advised that you wait until after you have had natural menstruation before attempting to conceive if you cease taking this medication because you want to become pregnant.

Interaction

• HIV medications (atazanavir/cobicistat, ospemifene, tamoxifen, and tizanidine), medications for the treatment of chronic hepatitis C (ombitasvir/paritaprevir, and ritonavir), medications for the treatment of hypertension (losartan, valsartan, and enalapril), and analgesics may interfere with Yasmin Tablet 21. (Ibuprofen, naproxen).
  Interactions between drugs and diseases include those involving hyperkalemia, irregular vaginal hemorrhage, cancer, hypercalcemia (increased calcium level in breast cancer), and hypertension. Yasmin Tablet 21 may also combine with other drugs. (high blood pressure).
• It is advised that a non-hormonal back-up means of contraception be used in addition to the usual consumption of Rosen 28 when Rosen 28 is used concurrently with other medications that may cause reduced ethinylestradiol serum concentrations.

Contraindications

In the event of any of the following circumstances, preparations having estrogen/progestogen combinations should not be used. The use of the product should be halted right away if any of the symptoms manifest for the first time while being used.

• Signs of an ocular blood clot (such as sudden loss of vision or painless blurring of vision)
• Cardiac attack warning signs (chest pain, pressure, heaviness in the chest, abnormal heartbeat, extreme weakness, anxiety, or shortness of breath, sweating, nausea, vomiting, or dizziness)
• Stroke warning signs (sudden weakness or numbness of the face, arm, or legs, especially on one side of the body, confusion, trouble in speaking or understanding, walking, dizziness, loss of balance, fainting with or without seizure)
• Intense stomach discomfort, swelling, and a small amount of blue discoloration on a limb
• Depressed and considering hurting or murdering yourself
• (Arterial or Venous) thrombosis, either current or past (e.g. deep venous thrombosis, pulmonary embolism, myocardial infarction, cerebrovascular accident)
• The presence or previous incidence of thrombus prodromi (e.g.transient ischaemic attack, angina pectoris)
• Migraines with localized neurological complaints, present or past
  diabetic arterial involvement in addition to diabetes
• Disturbed Lipometabolism
• A contraindication could also be the existence of serious or numerous risk factors for venous or arterial thromboembolism.
• Pancreatitis, or a history of it, if it is brought on by extremely high triglycerides
• Uterine hemorrhaging that is undiagnosed
• Existing or suspected pregnancy
• Hypersensitivity to any of the tablet's ingredients
• Severe hepatic disease present or previously present, as long as liver function levels have not yet been restored to normal
• Sudden renal failure or severe renal impairment
• Liver cancer now or in the past (benign or malignant)
• Breast or genital cancer that has been known or believed to be affected by sex steroids

Pregnancy & Lactation

Use During Pregnancy: 

• Rosen 28 delivery is not advised while pregnant. A woman must rule out pregnancy before beginning Rosen 28. Rosen 28 needs to stop being used right away if conception develops while taking it.
  There is no evidence that oral contraceptives harm the developing fetus or raise the risk of abortion in women who stop using them before getting pregnant. However, it is advised to use a non-hormonal means of contraception for three months before trying to procreate in women who stop using oral contraceptives with the intention of getting pregnant.

Utilization During Breastfeeding: 

• Estrogen-based oral contraceptives administered during the postpartum phase may hinder breastfeeding. The amount of breast milk may diminish, and its composition may alter. The milk of women who use contraceptives has also been found to contain trace quantities of their metabolites and/or steroids. Jaundice and breast growth are just two of the negative effects that have been documented. Till the baby has been fully withdrawn, estrogen-containing oral contraceptives should not be used.

Precautions & Warnings

• If you experience inexplicable chest discomfort, shortness of breath, an intense headache, or changes in your eyesight, stop taking these
• Rosen 28 and call your doctor immediately. These signs of a blood blockage in a capillary may exist.
• If your skin or the whites of your eyes start to turn yellow (jaundice), if you experience extreme sadness or excruciating stomach pain, or if you suspect you might be pregnant, stop taking Rosen 28 and call your doctor right away.
• When administering Rosen 28 to elderly ladies, care is advised. Therefore, before using it, talk to your doctor.

Storage Conditions

Store in a cool and dry place. Keep away from light & out of reach of children.