Propranol 10mg Tablet

Uses of Propranol 10mg Tablet

• Hypertension
• Angina pectoris
• Migraine prevention
• Hypertrophic subaortic stenosis
• Heart attack
• Pheochromocytoma
• Arrhythmias

How does Propranol 10mg Tablet work?

Propranol 10mg Tablet works by reducing the blood pressure by blocking the beta2 receptors present on the heart which are responsible for the increased blood pressure. It also relaxes the blood vessels which enhance proper blood flow in the body.

Side Effects of Propranol 10mg Tablet

• Headaches
• Feeling tired, dizzy, or weak
• Cold fingers or toes
• Feeling or being sick (nausea or vomiting)
• Diarrhea
• Stomach pain

Quick Suggestions:

• Propranol 10mg Tablet is prescribed for the treatment of various cardiovascular conditions, including high blood pressure, heart-related chest pain (angina), and irregular heartbeats. It's crucial to use this medication strictly under medical prescription and for the duration prescribed by your healthcare provider.
• Before starting Propranol 10mg Tablet, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Also, provide information about any other medications, supplements, and medical conditions you have.
• If you have an allergy to Propranolol or any components of Propranol 10mg Tablet, discuss this with your doctor before taking the medication.
• Remember, missing a dose of your blood pressure medication can have serious health consequences. If you forget to take a dose, try to take it as soon as you remember.

In addition to adhering to the prescribed medication schedule, making certain lifestyle changes is recommended. These changes include:

• Following a low-fat, low-salt diet
• Maintaining a healthy weight
• Engaging in 30 minutes of exercise daily
• Avoiding smoking
• Limiting alcohol consumption

Indication

Propranol 10mg Tablet is prescribed for the management of various medical conditions:

Hypertension: Hypertension, or high blood pressure, occurs when blood forcefully presses against blood vessel walls. Propranol 10mg Tablet is used alone or with other antihypertensive medications to treat high blood pressure, which may result from genetic or environmental factors.

Angina Pectoris: Angina pectoris is characterized by chest pain that radiates to the arms, neck, and back. Propranol 10mg Tablet is utilized to decrease the frequency of chest pain episodes and enhance exercise tolerance in angina patients.

Migraine Prevention: Migraine is marked by throbbing headaches with or without visual disturbances. While the effectiveness of Propranol 10mg Tablet in alleviating migraine headaches is uncertain, it is employed to prevent their occurrence.

Hypertrophic Subaortic Stenosis: This condition involves abnormal thickening of the heart muscle, reducing its pumping capacity. Propranol 10mg Tablet is used to ameliorate symptoms in individuals with hypertrophic subaortic stenosis.

Heart Attack Treatment and Prevention: A heart attack causes heart muscle death, resulting in impaired pumping ability. Propranol 10mg Tablet treats or prevents heart attacks, enhancing survival rates after an attack.

Pheochromocytoma: Pheochromocytoma is a rare adrenal gland tumor. Adrenal glands release hormones that regulate blood pressure. Propranol 10mg Tablet addresses symptoms linked to adrenal gland tumors.

Arrhythmia Management: Arrhythmia signifies an irregular heartbeat. Propranol 10mg Tablet is used to regulate heartbeats in patients with arrhythmia.

These therapeutic uses highlight the versatility of Propranol 10mg Tablet in managing a range of cardiovascular and neurological conditions. Always adhere to your healthcare provider's instructions when using this medication.

Pharmacology

Propranolol Hydrochloride is a medication that functions by blocking B-adrenergic receptors, and it's commonly prescribed for treating hypertension (high blood pressure) and angina pectoris (chest pain). By acting as an antagonist to catecholamines at B-adrenergic receptors, Propranolol curbs the heart's tendency to contract excessively quickly or forcefully, thereby reducing the demand for oxygen by the heart muscle.

Upon oral administration, Propranolol is almost entirely absorbed through the gastrointestinal tract, although a portion is metabolized by the liver as it enters the portal circulation. Following oral ingestion, the concentration of Propranolol in the blood peaks within the span of 1 to 1.5 hours. The drug has a plasma half-life of approximately 3 to 6 hours. Metabolites of Propranolol are eventually eliminated from the body through the urinary system.

Dosage & Administration of Propranol 10mg Tablet

For adults (above 18 years):

Hypertension:

• Begin with 80 mg twice daily.
• The dosage can be increased weekly.
• The recommended maintenance dose is 160-320 mg daily.

Angina Pectoris:

• Start with 40 mg 2-3 times daily.
• The maintenance dose is 120-240 mg daily.

Thyrotoxicosis:

• Take 10-40 mg, 3-4 times daily.

Anxiety:

• Begin with 40 mg once daily.
• Can be increased to three times daily.

Prophylaxis of Migraine:

• Start with 40 mg 2-3 times daily.
• The recommended maintenance dose is 80-160 mg daily.

For children (from day 1 to 18 years):

1. Hypertension:
   • Neonate: Begin with 0.25-0.5 mg/kg 3 times daily, adjust based on response.
   • Child (1 month to 12 years): Start with 0.25-1 mg/kg 3 times daily, with a maximum of 5 mg/kg daily in divided doses.
   • Child (12-18 years): Begin with 80 mg twice daily, and maintain 160-320 mg daily.

When taking Propranol 10mg Tablet:

• Follow your physician's instructions.
• Swallow the medicine with water; do not crush or chew it.
• Taking it around the same time each day is preferable, and it's recommended to take it before meals.

Remember:

• Your doctor will determine the appropriate dosage and duration based on your age, weight, and health status.
• Do not discontinue Propranol 10mg Tablet without your doctor's advice.

Interaction

Propranol 10mg Tablet has several interactions with other drugs, foods, and diseases that need to be considered:

Drug-Drug Interactions:

• There is a risk of dangerous heart rate reduction if Propranol 10mg Tablet is used alongside other beta-blockers (like acebutolol, atenolol, bisoprolol, etc.).
• Avoid combining Propranol 10mg Tablet with other blood pressure-related medications (lisinopril, enalapril, diltiazem, etc.), asthma drugs (theophylline), or painkillers.
• Inform your doctor if you're using these medications before taking Propranol 10mg Tablet.

Drug-Food Interactions:

• Grapefruit and protein-enriched foods can significantly interact with Propranol 10mg Tablet, potentially altering its effects.
• Avoid using Propranol 10mg Tablet concurrent with ayurvedic, homeopathic, Unani, herbal supplements, or OTC products, as they might diminish the medication's efficacy.
• Maintain a minimum 2-hour gap between the administration of Propranol 10mg Tablet and these products.

Drug-Disease Interactions:

• Individuals with diabetes, thyroid disorders, asthma, cardiogenic shock (heart's inability to pump blood), heart valve issues (stenosis), low blood pressure (hypotension), coronary heart disease, liver disease, or heart failure should not take Propranol 10mg Tablet.

Considering these interactions is crucial for ensuring the safety and effectiveness of Propranol 10mg Tablet. Always consult your healthcare provider before starting or stopping any medications, and inform them of your medical history, current medications, and any dietary supplements you are taking.

Contraindications

• If you are allergic to Propranolol or any other ingredients of Propranol 10mg Tablet.
• If you have low blood pressure.
• If you have asthma or other breathing difficulties.
• If you have any past medical history of heart failure.
• If you have severe heart disorders.

Pregnancy & Lactation

Pregnancy category C should not be utilized by women who are pregnant. Human milk contains propranolol, which is eliminated. When administering propranolol to a breastfeeding mother, extreme caution is advised.

Precautions & Warnings

Propranol 10mg Tablet should be used with caution and following specific guidelines:

• It should not be used in cases of cardiogenic shock (when the heart is unable to pump enough blood) and heart failure.
• Do not stop taking Propranol 10mg Tablet abruptly without consulting your doctor. Sudden discontinuation can lead to changes in heart rhythm and blood pressure, potentially causing chest pain or a heart attack. Your doctor will gradually lower the dose over time to prevent such complications.
• This medication is not suitable for individuals with a very slow heartbeat, asthma, serious heart conditions like sick sinus syndrome, or any heart blockages.
• Children weighing less than 4.5 pounds should not be given Propranol 10mg Tablet. It's also not recommended for children under 12 years of age.
• Prior to taking Propranol 10mg Tablet, inform your doctor if you have conditions such as muscle disorders (myasthenia gravis, rhabdomyolysis), breathing problems (COPD, bronchitis, emphysema), low blood sugar (hypoglycemia), low blood pressure (hypotension), depression, a history of heart failure, liver or kidney disease, thyroid hormone disorder, adrenal gland cancer, or issues with circulation (Raynaud's syndrome).
• Do not discontinue Propranol 10mg Tablet before undergoing surgery. It can mask symptoms of diabetes, so individuals with type 1 or type 2 diabetes should inform their doctor.
• Propranol 10mg Tablet may exacerbate symptoms of congestive heart failure and bradycardia (slow heart rate less than 60).
• If taking anti-coagulants like warfarin alongside Propranol 10mg Tablet, regular monitoring of prothrombin time is advised.

Storage Conditions

Store Propranol 10mg Tablets at room temperature and away from direct sunlight, heat, moisture. Keep it away from children and pets. The expired medication should be discarded via proper disposal methods and not used in any way.