MET 500mg Tablet 10pcs

Uses of MET 500

Type 2 Diabetes Mellitus, Polycystic Ovary Syndrome (PCOS), Obesity, Cardiovascular Diseases, Hypertension, 

How does MET 500 work?

Metformin, the active ingredient, is a biguanide with antihyperglycaemic effects. It lowers both basal and postprandial plasma glucose by various mechanisms.

Side Effects of MET 500

Common side effects include anorexia, nausea, vomiting, diarrhea, weight loss, occasional metallic taste, weakness, hypoglycemia, rash, and malabsorption of vitamin B12.

Quick Suggestions:

• Follow the diet and exercise program recommended by your doctor to effectively control diabetes.
• Regularly monitor blood sugar levels to detect and manage hypoglycemia, especially when combined with other antidiabetic medicines or alcohol.
• Inform your doctor if you experience symptoms like deep or rapid breathing, persistent nausea, vomiting, or stomach pain, as these may indicate a rare but serious condition called lactic acidosis.
• Prolonged use of Met 500 may lead to vitamin B12 deficiency, resulting in anemia. Notify your doctor if you experience symptoms like fatigue, pale skin, shortness of breath, or headache.
• Your doctor will regularly monitor blood sugar levels and kidney functions while you are on Met 500.

Indications of Metformin Hydrochloride

Type II Diabetes Mellitus:

Diabetes mellitus (DM) is a health condition characterized by elevated blood sugar levels. It occurs due to insufficient insulin production or the body's inability to effectively use insulin. Insulin is a hormone produced by the pancreas, and it plays a crucial role in converting glucose from food into energy. There are two main types of diabetes:

• Type I DM: This type involves little to no production of insulin by the pancreas.
• Type II DM: This type is characterized by insulin resistance, where the body's cells do not respond properly to insulin. MET 500 Tablet is used to help regulate blood glucose levels in individuals with type 2 diabetes, both in adults and children.

Polycystic Ovary Syndrome (PCOS):

Polycystic ovary syndrome is a hormonal disorder affecting women of reproductive age. It involves the enlargement of ovaries with cysts formed on the outer lining. PCOS is associated with hormonal imbalances, irregular menstrual cycles, and other symptoms. MET 500 Tablet is sometimes used in the treatment of PCOS.

MET 500 Tablet:

• Usage in Type 2 Diabetes: Helps in reducing blood glucose levels by addressing insulin resistance.
• Usage in PCOS: Can be used in the management of Polycystic ovary syndrome to address hormonal imbalances.

Pharmacology

• Reduces both baseline and postprandial plasma glucose levels.
• Differs from sulfonylureas and does not induce hypoglycemia.
• Enhances insulin sensitivity.
• Increases peripheral glucose uptake and utilization.
• Lowers hepatic glucose production.
• Reduces intestinal glucose absorption.
• Metformin is effective in treating type 2 diabetes by targeting multiple aspects of glucose metabolism.
• It is known for improving insulin sensitivity, reducing glucose production by the liver, and decreasing intestinal glucose absorption.
• Unlike some other antidiabetic medications, metformin does not stimulate insulin secretion, minimizing the risk of hypoglycemia.
• The overall effect is a better control of blood sugar levels in individuals with type 2 diabetes.

Dosage & Administration of Metformin Hydrochloride

• The initial dose varies for type 2 diabetes and PCOS. Adjustments are made based on the patient's condition and response to treatment.
• Contraindicated in severe renal impairment. Regular monitoring is essential for those at risk for renal impairment.
• Take Met 500 with food to avoid nausea and abdominal pain. Consistency in timing is crucial for optimal benefits.

Interaction

Additive effects with sulfonylureas. Thiazide diuretics, corticosteroids, phenothiazines, oral contraceptives, sympathomimetics, niacin, calcium channel blockers, isoniazid, and ACE inhibitors may affect glycaemic control. Potential fatal interaction with iodinated contrast agents.

Contraindications

Avoid acute or chronic metabolic acidosis, renal failure, severe renal or hepatic impairment, dehydration, severe infection, shock, cardiac failure, congestive heart failure (CHF), insulin-dependent diabetes mellitus (IDDM), severe thyroid impairment, acute or chronic alcoholism, and conditions causing tissue hypoxia.

Metformin Hydrochloride during Pregnancy & Lactation

Pregnancy:

• Uncontrolled diabetes during pregnancy (gestational or permanent) increases the risk of birth defects and perinatal mortality.
• It is advised not to use metformin to treat diabetes when planning to become pregnant and during pregnancy.
• Insulin is recommended during pregnancy to maintain blood sugar levels as close to normal as possible, reducing the risk of fetal malformations.

Breastfeeding:

• Metformin is excreted in human milk.
• No adverse reactions were observed in breastfed newborns/infants.
• Limited data is available; breastfeeding during metformin treatment is not recommended.
• The decision to continue breastfeeding should consider the benefits and potential risks of adverse effects on the child.

Precautions & Warnings

Exercise caution in patients with CHF, risk of lactic acid accumulation, and during stress-related states. Temporary discontinuation may be necessary for certain medical procedures.

Storage Conditions

• Store MET 500mg Tablet below 25°C at a cool and dry place.
• Protect it from direct sunlight and moisture.
• Keep it out of reach of children and pets.