Livacol 5mg Tablet | 10pcs | Obeticholic Acid | Price | Buy from ePharma
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Livacol 5mg Tablet

Generic: Square Pharmaceuticals Ltd.

Type: Tablet

Pack Size: 10 Pcs

Obeticholic acid is used in the treatment of Primary biliary cirrhosis.


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Discount Price: ৳ 279
MRP: ৳ 300 7% Off

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Description:

Livacol 5mg Tablet contains Obeticholic acid, a medication classified as a Farnesoid X receptor agonist. It is prescribed for the treatment of primary biliary cholangitis (PBC), also known as primary biliary cirrhosis, in adults. PBC is a chronic liver disorder characterized by the gradual destruction of bile ducts in the liver, leading to the accumulation of bile and resulting in liver inflammation and scarring.

  • Livacol 5mg Tablet should not be used by pregnant women. If you are pregnant or planning to become pregnant, consult your doctor before starting this medication.
  • Breastfeeding women should also consult their doctor before taking Livacol 5mg Tablet.
  • The medication is not recommended for children and adolescents under the age of 18 and should be used with caution in elderly patients aged 65 and above.
  • Before initiating treatment with Livacol 5mg Tablet, your doctor may recommend blood tests to assess your liver function.

Safety Advices


Alcohol
UNSAFE

The potential interaction of Livacol 5mg Tablet with alcohol is not known. If you have any concerns or questions about alcohol consumption while taking this medication, consult your doctor.


Pregnancy
UNSAFE

If you are pregnant or planning to become pregnant, it is advisable to consult your doctor before using the Livacol 5mg Tablet. Limited information is available regarding its use during pregnancy, and your doctor can provide guidance based on your specific situation.


Breastfeeding
CONSULT YOUR DOCTOR

For breastfeeding mothers, it is essential to consult your doctor regarding the use of Livacol 5mg Tablets. Your doctor will assess whether it can be taken while breastfeeding, taking into consideration both the potential benefits and risks.


Driving
CAUTION

Livacol 5mg Tablet is considered safe for driving if it is prescribed to you. However, if you experience dizziness as a side effect, you are advised to avoid driving or operating heavy machinery.


Kidney
CONSULT YOUR DOCTOR

If you have kidney impairment or any concerns regarding your kidney health, consult your doctor. They can assess your condition and provide guidance on the safe use of Livacol 5mg Tablet.


Liver
CONSULT YOUR DOCTOR

If you have a liver impairment or any concerns related to your liver, it's important to consult your doctor. Dose adjustments may be necessary, and your doctor can provide specific guidance based on your liver condition.

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Uses:

Primary biliary cirrhosis

How does Livacol 5mg Tablet work?

Livacol 5mg Tablet works by reducing the production and build-up of bile in the liver and also reduces the inflammation of the liver. Therefore, as a result, it helps to improve liver function.

Side Effects of Livacol 5mg Tablet
  • Stomach pain
  • Tiredness
  • Dizziness
  • Palpitations (irregular or fast heartbeat)
  • Constipation
  • Thyroid hormone irregularity
Quick Suggestions:
  • Primary Biliary Cholangitis (PBC) predominantly affects women, although there is an increasing number of men being diagnosed with the condition.
  • PBC is characterized by the chronic inflammation and eventual destruction of the small bile ducts in the liver. In the United States, it is estimated that approximately 65 out of every 100,000 women have PBC.
  • This disorder typically becomes apparent during middle age, with the majority of affected individuals falling within the age range of 45 to 65 years.
  • While there is no known cure for PBC, there are medications available to help manage the disease and slow down the progression of liver damage.
Indication

Livacol 5mg Tablet is used for the treatment of primary biliary cholangitis (PBC) in adults, Which is done in adult people with ursodeoxycholic acid combination, People in whom ursodeoxycholic acid has not responded adequately.

Pharmacology

Obeticholic acid is an FXR agonist, which means it activates the Farnesoid X receptor (FXR). FXR is a nuclear receptor found in various tissues, including the liver, intestine, kidney, and adipose tissue. It plays a crucial role in regulating a wide range of target genes involved in controlling:

  • Bile acid synthesis and transport: FXR activation reduces the production of new bile acids (de novo synthesis) in hepatocytes (liver cells). Additionally, it enhances the transport of existing bile acids out of hepatocytes. This combined effect helps lower the exposure of hepatocytes to bile acids, which can be damaging.
  • Lipid metabolism: FXR has a role in regulating the metabolism of lipids (fats), including cholesterol, in the body.
  • Glucose homeostasis: FXR also influences the regulation of glucose (sugar) levels in the body, helping to maintain stable blood sugar levels.

In the context of primary biliary cholangitis (PBC), Obeticholic acid's activation of FXR can lead to a reduction in bile acid buildup within the liver and mitigate some of the harmful effects associated with PBC.

Dosage & Administration

The recommended dosing regimen for Obeticholic Acid in adults with Primary Biliary Cholangitis (PBC) is as follows:

Noncirrhotic or compensated Child-Pugh class A:

  • Starting dose: 5 mg orally once daily (qDay).
  • Dosage titration: If an adequate response has not been achieved after 3 months at 5 mg/day and the medication is being tolerated, increase the dose to 10 mg once daily.
  • The maximum recommended dose for this category is 10 mg/day.

Child-Pugh class B or C, or prior decompensation event:

  • Starting dose: 5 mg orally once weekly.
  • Dosage titration: If an adequate response has not been achieved after 3 months at 5 mg once weekly and the medication is being tolerated, increase the dose to 5 mg twice weekly (at least 3 days apart).
  • If necessary, the dose may be titrated up to 10 mg twice weekly (at least 3 days apart) based on response and tolerability.
Missed Dosage of Livacol 5mg Tablet

If you miss a dose of Obeticholic Acid, try to take it as soon as you remember. However, if it's close to the time for your next scheduled dose, it's best to skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

Overdose of Livacol 5mg Tablet

In the event of a suspected overdose of Obeticholic Acid, do not exceed the prescribed dose. Contact your doctor immediately for further guidance and medical advice.

Interaction
  • Some medicines can affect the way Obiholic Tablet works or this Tablet itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
  • The use of Obiholic Tablet with bile acid binding resins (cholestyramine, colestipol, colesevelam) may reduce the effectiveness of this Tablet.
  • Particular care should be taken if you are using medicines to treat asthma/chronic obstructive pulmonary disorder (theophylline), muscle cramps (tizanidine), and blood clots (warfarin).
Contraindications

You should not take Livacol 5mg Tablet if:

  • You are allergic to obeticholic acid or any other ingredient of the tablet.
  • You have a complete blockage of the bile ducts in your liver or gallbladder.
Pregnancy & Lactation

The little human data on Obeticholic Acid consumption during pregnancy is insufficient to establish a drug-associated danger. There is no information on Obeticholic Acid's presence in human milk, its effects on breastfed infants, or its impact on milk production.

Precautions & Warnings

Allergic Reactions: Do not take Livacol 5mg Tablet if you are allergic to any of its components. If you experience severe itching that is difficult to tolerate, inform your doctor.

Biliary Tract Blockage: This medication is not suitable if you have a complete blockage of the biliary tract, which includes the liver, bile ducts, and gall bladder. Your doctor will consider your medical history and condition before prescribing Livacol 5mg Tablet.

Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, it is essential to consult your doctor before using the Livacol 5mg Tablet. Your doctor can assess the potential risks and benefits in your specific situation.

Not for Children or Adolescents: Livacol 5mg Tablet is not recommended for use in children or adolescents. It should only be used in adults.

Dizziness: This medication may cause dizziness as a side effect. If you experience dizziness while taking Livacol 5mg Tablet, exercise caution, especially when driving or operating heavy machinery.

Seek Immediate Medical Attention: Consult a doctor immediately if you experience any of the following symptoms or conditions while taking Livacol 5mg Tablet:

  • Yellowing of the skin or eyes
  • Black or tarry stools
  • Dark urine
  • Coughing up or vomiting blood
  • Confusion
  • Slurred speech
  • Mood swings
  • Anxiety
  • Swelling in and around the stomach
Storage Conditions
  • Store in a cool and dry place away from direct sunlight.
  • Keep out of reach of children and pets.
Frequently Asked Questions (FAQ)

Livacol 5mg Tablet is not recommended for use in patients with complete blockage of the biliary tract (liver, gall bladder and bile ducts). Consult your doctor before taking OBETOHEP 10MG.

Livacol 5mg Tablet may cause palpitation, a sensation that the heart is racing, pounding, or fluttering. A minor fluctuation should not be a worry; however, if palpitations continue or you begin to feel unwell, speak with your doctor.

Do not discontinue Livacol 5mg Tablet without consulting your doctor. To treat your condition effectually, continue taking Obstela 5 Tablet 10's for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Obstela 5 Tablet 10's.
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Check our pricing section for Livacol 5mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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