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Lijenta-M 500mg 10pcs

10pcs Tablets. Each film coated tablet contains Linagliptin INN 2.5 mg and Metfromin Hydrochloride BP 500 mg.

Generic: Linagliptin + metformin hydrochloride

Type: Capsule

Pack Size: 10 Pcs

MRP 120 8% off
110.4
Inclusive of all taxes

Information about Lijenta-M 500mg 10pcs

Indications: This is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both linagliptin and metformin is appropriate.

Pharmacology: Ccombination of Linagliptin, a DPP-4 inhibitor & Metformin, a member of the biguanide class) with complementary mechanisms of action to improve glycemic control in patients with type 2 diabetes mellitus.


Linagliptin: Linagliptin is an inhibitor of DPP-4, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Thus, Linagliptin increases the concentrations of active incretin hormones, stimulating the release of insulin in a glucose-dependent manner and decreasing the levels of glucagon in the circulation. Both incretin hormones are involved in the physiological regulation of glucose homeostasis. Incretin hormones are secreted at a low basal level throughout the day and levels rise immediately after meal intake. GLP-1 and GIP increase insulin biosynthesis and secretion from pancreatic beta cells in the presence of normal and elevated blood glucose levels. Furthermore, GLP-1 also reduces glucagon secretion from pancreatic alpha cells, resulting in a reduction in hepatic glucose output.

Metformin: Metformin lowers both basal and postprandial plasma glucose. It does not stimulate insulin secretion and therefore does not produce hypoglyceamia or increased weight gain. Metformin may exert its glucose-lowering effect via four mechanisms:
 

  • by reduction of hepatic glucose production through inhibition of gluconeogenesis and glycogenolysis;
  • in muscle, by modestly increasing insulin sensitivity, improving peripheral glucose uptake and utilization;
  • by delaying intestinal glucose absorption;
  • stimulate intracellular glycogen synthesis by acting on glycogen synthase and increase the transport capacity of glucose transporters (GLUT-1 & GLUT-4)
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