Exelon Transdermal Patch 5cm (30pcs Box)

Uses of Exelon Transdermal Patch 5cm

• Treat Alzheimer’s dementia and dementia due to Parkinson’s disease

How does Exelon Transdermal Patch 5cm work?

Exelon Transdermal Patch 5cm works by blocking the enzymes that break down acetylcholine. By blocking the enzymes, it increases the levels of acetylcholine in the brain that helps in reducing the symptoms of dementia associated with Alzheimer's disease and Parkinson’s disease.

Side Effects of Exelon Transdermal Patch 5cm

• Vomiting
• Diarrhea
• Stomach upset
• Stomach pain
• Headache
• Anxiety
• Depression/low mood
• Trouble sleeping
• Dizziness
• Drowsiness
• Shakiness (tremor)
• Weakness/tiredness
• Weight loss/loss of appetite
• Skin irritation at the application site

Quick Suggestions:

• You have been prescribed Exelon Patch 10 to slow down the progression of Alzheimer's disease.
• It does not cure Alzheimer's disease but may help improve brain function and the ability to do daily activities.
• Exelon Patch 10 is absorbed through the skin continuously. This produces steady blood levels of the medicine.
• To prevent skin irritation, change the location of the patch every day.
• Do not apply the patches to broken, red, or irritated skin.
• It may cause diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated while taking Exelon Patch 10.
• Do not drive or do anything that requires mental focus until you know how Exelon Patch 10 affects you.
• Inform your doctor if you notice sensitivity and irritation in and around the area where the patch is placed and if it doesn't go away after the patch is removed.

Indications:

Alzheimer's Disease:

• Definition: A neurological disorder leading to dementia, named after Dr. Alois Alzheimer.
• Characteristics:
  • Causes memory loss and impairs cognitive functions.
  • Gradually diminishes the ability to think, learn, communicate, and handle daily activities.
• Prevalence:
  • Most common cause of dementia in adults.
• Causes:
  • Abnormal functioning of brain cells disrupt communication.
• Risk Factors:
  • Age, family history, and genetics.
• Symptoms:
  • Memory loss, difficulty with tasks, problem-solving challenges, disorientation, mood and personality changes.
• Onset:
  • Symptoms often appear in mid-60s.

Parkinson's Disease:

• Definition: Central nervous system disorder affecting movement, characterized by tremors, stiffness, and difficulty with coordination.
• Characteristics:
  • Affects nerve cells producing dopamine (neurotransmitter).
• Symptoms:
  • Dementia, muscle rigidity, tremors, changes in speech, and gait abnormalities.
• Onset:
  • Occurs typically in people aged 60 years and over.
• Risk Factors:
  • Genetics, environmental triggers, and exposure to certain toxins.

Pharmacology:

Rivastigmine is a carbamate derivative that shares similarities with physostigmine but differs from donepezil or tacrine in its structure. While the precise mechanism of rivastigmine remains unknown, it is believed to reversibly bind to and deactivate cholinesterase enzymes, including acetylcholinesterase and butyrylcholinesterase. This action inhibits the hydrolysis of acetylcholine, leading to an increase in acetylcholine levels at cholinergic synapses. Notably, rivastigmine's anticholinesterase effects are relatively selective for brain acetylcholinesterase and butyrylcholinesterase compared to peripheral tissues.

Dosage & Administration:

Parkinson Dementia: Transdermal

• Initial: Apply 4.6 mg patch every 24 hours
• May increase the dose to 9.5 mg patch every 24 hours after a minimum of 4 weeks if well-tolerated; after an additional 4 weeks, may further increase to 13.3 mg patch if needed

Transdermal in Mild-to-moderate hepatic impairment: Not to exceed 4.6 mg patch every 24 hours

Renal Dose for Transdermal: No dosage adjustment is required

To apply the Transdermal Patch:

• Choose a suitable area: Select a clean, dry, and healthy skin area without hair. The upper or lower back, upper arm, or chest are recommended areas.
• Clean the skin: Ensure that the chosen area is clean and free from any creams, oils, lotions, or powder.
• Avoid damaged skin: Do not apply the patch on damaged or broken skin to prevent irritation.
• Remove old patch: If you are already using a patch, do not apply a new one until it's time to replace the old patch. Applying a new patch on top of an existing one can lead to overdosing.
• Apply the patch evenly: Place the patch evenly on the skin surface. Press it down firmly to ensure good adhesion.

Interaction

Drug-Drug Interaction: Exelon Patch 10 may interact with the following drugs:

• Painkillers (aspirin, naproxen)
• Vomiting medicines (metoclopramide)
• Drugs treating frequent urination (oxybutynin, tolterodine)
• High blood pressure medicine (atenolol)

Drug-Food Interaction: Avoid consuming alcohol while using Exelon Patch 10, as it could lead to increased dizziness and drowsiness.

Drug-Disease Interaction: Before using Exelon Patch 10, inform your doctor if you have any of the following conditions:

• Liver or kidney diseases
• Breathing problems (asthma, chronic obstructive pulmonary disease (COPD))
• Stomach/intestinal problems (ulcers, bleeding)
• Heart diseases (sick sinus syndrome and conduction disorders)
• Fainting
• Fits
• Urination problems
• Enlarged prostate

Pregnancy & Lactation

Pregnancy:

• There are no clinical data on Rivastigmine's safety during pregnancy.
• Rivastigmine should only be taken if absolutely required during pregnancy.
• It's crucial for pregnant individuals to consult with their healthcare provider to weigh the potential benefits and risks.

Lactation:

• Rivastigmine is secreted in milk by animals, indicating a potential transfer to human milk.
• There is no information on whether rivastigmine is excreted in human milk.
• As a precaution, women who are on rivastigmine are advised not to breastfeed.
• Breastfeeding decisions should be made in consultation with a healthcare professional considering the potential risks to the infant.

Precautions & Warnings

Patients with Sick Sinus Syndrome or Conduction Abnormalities:

• Caution is advised in patients with sick sinus syndrome or conduction abnormalities.

Patients with Respiratory Disorders:

• Use with caution in patients with respiratory disorders, as cholinergic activation may increase gastric acid production.

Gastric Acid Production:

• Cholinergic activation may increase gastric acid production, so monitoring is recommended.

Urinary Obstruction and Convulsions:

• Exelon Patch 10 may worsen urinary obstruction and convulsions, and caution is advised.

Pregnancy:

• Use during pregnancy is cautioned. Consult with your doctor before using Exelon Patch 10 if you are pregnant.

Renal Failure:

• Caution is advised in patients with renal failure.

Mild to Moderate Hepatic Failure:

• Monitor carefully in patients with mild to moderate hepatic failure.

Weight Monitoring for Asthma or Obstructive Pulmonary Disease:

• Patients with asthma or obstructive pulmonary disease should monitor their weight carefully.

Extrapyramidal Symptoms:

• Extrapyramidal symptoms may become worse, so use caution.

Lactation:

• Use caution during lactation, and it's advisable to consult with a healthcare professional.

Storage Conditions

Store in a cool and dry place, protected from light.