Entrovas 50 | Sacubitril + Valsartan | 24mg+26mg | ePharma
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Entrovas 50mg Tablet

Generic: Sacubitril + Valsartan

Type: Tablet

Pack Size: 10 Pcs

Entrovas 50mg Tablet combines Sacubitril and valsartan to combat heart failure.


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Discount Price: ৳ 418.5
MRP: ৳ 450 7% Off

⪼ Save  ৳: 31.5  in this Product


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Description:

Entrovas 50mg Tablet is a combination of Sacubitril and Valsartan, belonging to the Angiotensin receptor neprilysin inhibitors group. It is used to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (New York Heart Association Class II-IV) and reduce ejection fraction.

Heart Failure: Heart failure occurs when the heart is weak and unable to pump enough blood to the lungs and the rest of the body. It is characterized by symptoms such as breathlessness, fatigue, tiredness, and ankle swelling.

  • Inform your doctor if you have liver, kidney, or heart problems.
  • Not recommended for pregnant and breastfeeding women.
  • Not suitable for children and adolescents under 18 years.
  • Use with caution in elderly patients (65 years and above).
  • Inform your doctor about any previous allergies and medication history.

Safety Advices


Alcohol
UNSAFE

It is unsafe to consume alcohol while taking Entrovas 50mg Tablet. 


Pregnancy
CONSULT YOUR DOCTOR
  • Not recommended for use in early pregnancy.
  • Must not be used in pregnant women when more than 3 months pregnant, as it may cause serious harm to the baby.
  • Consult your doctor before taking Entrovas 50mg Tablet if you think you may be pregnant.

Breastfeeding
CONSULT YOUR DOCTOR
  • Contraindicated for use in breastfeeding women.
  • Consult your doctor before taking Entrovas 50mg Tablet if you are breastfeeding or about to start breastfeeding

Driving
CAUTION
  • Use with caution.
  • Avoid driving or handling machines while taking Entrovas 50mg Tablet because it may cause dizziness or tiredness.

Kidney
CAUTION
  • Use with caution in patients with severe kidney disease and narrowed kidney arteries.
  • Consult your doctor before taking Entrovas 50mg Tablet.

Liver
CAUTION
  • Not recommended for use in patients with severe liver disease.
  • Use with caution in patients with liver disease.
  • Consult your doctor before taking Entrovas 50mg Tablet.

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Uses:

Heart failure

How does Entrovas 50mg Tablet work?

It's a combination of Sacubitril and Valsartan. Sacubitril works by inhibiting the action of certain chemical substances that cause the narrowing of the blood vessels. Thus, it eases blood flow and allows your heart to pump blood more efficiently. Valsartan works by relaxing the blood vessels that allow the blood to flow more easily. 

Side Effects of Entrovas 50mg Tablet
  • Cough
  • Dizziness
  • Low blood pressure
  • Altered potassium levels in the blood
  • Decreased red blood cell count
  • Hypoglycemia (low blood glucose)
  • Diarrhea
  • Fainting
  • Headache
  • Nausea
  • Stomach pain
  • Vertigo
  • Weakness
Quick Suggestions:
  • Continue to stay active and maintain a low-sodium diet.
  • Rise slowly to reduce dizziness.
  • Avoid potassium supplements and potassium-rich foods.
  • Inform your doctor if you have kidney or liver disease.
  • Not recommended during pregnancy or breastfeeding.
Indications:

Entrovas 50 is used to treat chronic heart failure, reducing the risk of hospitalization and death. It should be taken regularly as prescribed by your doctor, even if you feel well. Side effects may include cough, dizziness, and low blood pressure.

Pharmacology

It's an angiotensin receptor-neprilysin inhibitor (ARNi) that relaxes blood vessels and blocks vasoconstrictor effects.

Dosage & Administration of Entrovas 50mg Tablet

Adult Dose: Heart Failure

To reduce the risk of cardiovascular death and hospitalization for heart failure (HF) in patients with chronic heart failure (CHF) (NYHA class II-IV) and reduced ejection fraction.

Recommended starting dose: 49 mg/51 mg PO BID.

Target maintenance dose: After 2-4 weeks, double the dose to the target maintenance dose of 97 mg/103 mg PO BID as tolerated.

Hepatic Impairment

Mild (Child-Pugh A): No starting dose adjustment is required.

Moderate (Child-Pugh B): Reduce starting dose to 24 mg/26 mg BID; double the dose every 2-4 weeks to target maintenance dose of 97 mg/103 mg BID as tolerated.

Severe (Child-Pugh C): Not recommended.

Renal Dose

Renal impairment Mild-to-moderate (eGFR ≥30 mL/min/1.73 m²): No starting dose adjustment required.

Severe (eGFR <30 mL/min/1.73 m²): Reduce starting dose to 24 mg/26 mg BID; double the dose every 2-4 weeks to target maintenance dose of 97 mg/103 mg BID as tolerated.

Interaction

Drug-Drug Interactions:

Pain medication (aspirin): Use caution when taking aspirin with Entrovas 50mg Tablet, as it may interact with this medication. Consult your doctor for guidance.

Medicine used to lower cholesterol (rosuvastatin, atorvastatin): Be cautious when using these cholesterol-lowering medications alongside Entrovas 50mg Tablet. Your doctor can provide specific recommendations.

Medicine to treat both type 1 and type 2 diabetes (insulin detemir): Monitor your blood sugar levels closely when using insulin detemir with Entrovas 50mg Tablet. Adjustments to your diabetes medication may be necessary.

Blood pressure medication (metoprolol): Take metoprolol as directed by your doctor while using Entrovas 50mg Tablet. Regular blood pressure monitoring is essential.

Medication used in the management of asthma (budesonide/formoterol): Consult your healthcare provider for guidance on using budesonide/formoterol alongside Entrovas 50mg Tablet.

Drug-Food Interaction:

  • Maintain a low-salt and low-fat diet while taking Entrovas 50mg Tablet. Avoid consuming foods rich in potassium, such as potassium-containing salt substitutes or over-the-counter potassium supplements. Additionally, refrain from smoking and alcohol consumption.

Drug-Disease Interactions:

Hypotension (low blood pressure): Use Entrovas 50mg Tablet with caution if you have low blood pressure.

Diabetes: Monitor your blood sugar levels closely while using this medication, especially if you have diabetes. Adjustments to your diabetes management may be necessary.

Angioedema (rapid edema or swelling beneath the skin): Be aware of the potential risk of angioedema when using Entrovas 50mg Tablet. Contact your doctor if you experience any signs of swelling.

Hyperkalemia (high potassium in the blood): Regularly monitor your potassium levels when taking Entrovas 50mg Tablet, as it may affect your potassium balance.

Renal artery stenosis: Use this medication cautiously if you have renal artery stenosis, a condition characterized by narrowed renal arteries.

Renal/liver disease: Inform your doctor about any existing renal or liver disease before starting Entrovas 50mg Tablet. Adjustments to the medication may be needed.

Renal impairment: If you have renal impairment, consult your doctor before using Entrovas 50mg Tablet. Dosing adjustments may be required.

Contraindications
  • Hypersensitivity to any component
  • History of angioedema related to ACE inhibitor or ARB therapy
  • Concomitant use of Aliskiren in diabetic patients
Pregnancy & Lactation
  • Use with caution during pregnancy.
  • Use in breastfeeding mothers only if clinically needed.
Precautions & Warnings
  • Entrovas 50 may increase the risk of side effects and worsen the condition.
  • May not affect your ability to drive.
  • Safe for use in patients with liver or kidney diseases if prescribed.
  • Can cause fetal harm during pregnancy.
  • Watch for signs of angioedema.
  • Monitor renal function and potassium levels.
  • Risk of hypotension, especially in volume-depleted patients.
Storage Conditions

Store in a cool, dry place.

Frequently Asked Questions (FAQ)

You should take Entrovas 50mg Tablet immediately when you remember. If it is time for your next dose skip the missed dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.

Talk to your doctor before taking potassium supplements, potassium-sparing diuretics, or salt substitutes along with Entrovas 50mg Tablet as it might cause an increase in serum potassium and serum creatinine levels.

It is advised to consult a doctor before use and take it at a fixed time in a day.

Entrovas 50mg Tablet should be avoided in patients who are allergic to any of its ingredients.

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Check our pricing section for Entrovas 50mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.
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