Centradol 50mg Tablet

Uses of Centradol 50mg Tablet

• Treats severe chronic pain in adults

How does Centradol 50mg Tablet work?

Centradol 50mg Tablet directly acts on the central nervous system to reduce the sensation of pain by interrupting the signaling of pain between the brain and the body. It binds to specific receptors known as µ-opioid receptors and enhances the release of norepinephrine, a nerve chemical. This mechanism inhibits certain receptors, ultimately providing relief from pain.

Side Effects of Centradol 50mg Tablet

• Nausea
• Dizziness
• Vomiting
• Somnolence
• Decreased appetite
• Anxiety
• Confusion
• Hallucination
• Sleep problem
• Abnormal dreams
• Trembling
• Flushing
• Constipation
• Diarrhoea
• Indigestion
• Dry mouth
• Itching
• Increased sweating
• Rash
• Muscle cramps
• Feeling of weakness
• Fatigue
• Feeling of body temperature change

Quick Suggestions:

• Tapentadol is a strong painkiller that is used in the treatment of moderate to severe pain when other treatments do not treat your pain well enough or you cannot tolerate it.
• The addiction / habit-forming potential of Tapentadol is very high. Take exactly as prescribed by your doctor.
• Use caution while driving or doing anything that requires concentration as Tapentadol can cause dizziness and sleepiness.
• While taking this medication, avoid alcohol in all forms including beer, wine, aftershave lotions, mouthwash, vinegar, certain desserts, colognes, and liquid medications.
• Inform your doctor if you have asthma, liver, kidney, or pancreatic disease, or are severely constipated.

Indication

Centradol 50mg Tablet is an opioid painkiller used to alleviate moderate to severe pain. Pain is an unpleasant sensory and expressive experience caused by real or potential tissue injury.

Pharmacology

Centradol 50mg Tablet, classified as an opioid, is a potent analgesic utilized to manage moderate to severe pain. Its pharmacological action involves direct interaction with opioid receptors in the central nervous system. By disrupting the transmission of pain signals between neurons, Centradol 50mg Tablet effectively alleviates pain originating from various medical conditions.

Dosage & Administration of

For the treatment of moderate to severe acute pain, the initial dose is typically 50 mg, 75 mg, or 100 mg, administered every 4 to 6 hours based on the intensity of pain. On the first day of treatment, an additional dose may be administered 1 hour after the initial dose if adequate pain relief is not achieved. Subsequent doses can be given every 4 to 6 hours, with adjustments made according to the patient's response. The maximum daily dose on the first day should not exceed 700 mg, while on subsequent days, it should not exceed 600 mg.

For elderly individuals, it is advisable to initiate the dosage at the lower end of the recommended range.

In cases of mild hepatic impairment, no dosage adjustment is typically required. However, for moderate hepatic impairment, the initial dosage is usually 50 mg every 8 hours, with a dosing frequency not exceeding 3 times daily. Centradol 50mg Tablet is generally not recommended for individuals with severe hepatic impairment.

Safety and efficacy data for pediatric use are not established.

In individuals with renal impairment, dosage adjustments are usually not necessary when creatinine clearance (CrCl) is greater than 30 mL/min. However, Centradol 50mg Tablet is generally not recommended for those with CrCl less than 30 mL/min.

It is important to take Centradol 50mg Tablet exactly as prescribed by your doctor. The medication should be swallowed whole with a glass of water and should not be crushed or chewed. Your doctor will determine the appropriate dose and treatment duration based on factors such as your age, body weight, and the specific medical condition being treated.

Interaction

Tapentadol may interact with various drugs, and it's important to be cautious. Some of the potential drug interactions include:

1. Antidepressants or antipsychotics (e.g., duloxetine, venlafaxine, escitalopram, desvenlafaxine, quetiapine, linezolid)
2. Tricyclic antidepressants (e.g., amitriptyline)
3. Anticonvulsants (e.g., pregabalin)
4. Narcotic analgesics (e.g., naloxone, oxycodone)
5. Medications for anxiety and seizures (e.g., diazepam, alprazolam)

It's essential to inform your doctor about all the medications you are taking, as these interactions can affect the way Tapentadol works or lead to potential side effects.

Regarding food interactions, it is advisable to avoid the consumption of alcoholic beverages while taking Tapentadol.

Tapentadol can also interact with various disease conditions, so it's crucial to be cautious if you have any of the following conditions:

1. Impaired GI motility
2. Infectious diarrhea
3. Liver disease
4. Prematurity
5. Acute alcohol intoxication
6. Drug dependence
7. Gastrointestinal obstruction
8. Hypotension
9. Intracranial pressure
10. Respiratory depression
11. Biliary spasm
12. Renal dysfunction
13. Seizure disorders
14. Urinary retention

Contraindications

Significant respiratory depression, especially in unmonitored settings or in the absence of resuscitative equipment. Tapentadol can affect breathing, so it should be used carefully, particularly in individuals with compromised respiratory function.

Acute or severe bronchial asthma or hypercapnia (elevated levels of carbon dioxide in the blood). Tapentadol may worsen respiratory conditions, making it a concern for individuals with these conditions.

Known or suspected paralytic ileus, a condition where the intestines are partially or completely blocked. Tapentadol can further slow down gut motility, exacerbating this condition.

Acute intoxication with substances such as alcohol, hypnotics, centrally acting analgesics or psychotropic drugs. Combining these substances with Tapentadol can increase the risk of central nervous system depression and other adverse effects.

Concurrent or recent (within 2 weeks) therapy with monoamine oxidase inhibitors (MAOIs), a class of antidepressants. Combining Tapentadol with MAOIs can lead to serious and potentially life-threatening interactions, such as serotonin syndrome.

Pregnancy & Lactation

There is little information available on the use of Tapentadol during pregnancy or while breastfeeding.

Precautions & Warnings

• Respiratory Conditions: Caution is necessary when administering Tapentadol to individuals with respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD), as it can affect respiratory function.
• Sleep Apnea Syndrome: Patients with sleep apnea syndrome should use Tapentadol with caution. This condition already involves interruptions in breathing during sleep, and Tapentadol can further affect breathing patterns.
• Myxedema: Tapentadol should be used cautiously in individuals with myxedema, a condition associated with severe hypothyroidism. Myxedema can affect metabolism and overall health.
• Kyphoscoliosis: In cases of kyphoscoliosis (an abnormal curvature of the spine), Tapentadol should be used with caution, as it may further compromise respiratory function.
• Central Nervous System (CNS) Depression: Patients taking other µ-opioid agonist analgesics, general anesthetics, phenothiazines, other tranquilizers, sedatives, hypnotics, or other CNS depressants, including alcohol, alongside Tapentadol may experience additive CNS depression. This can result in excessive drowsiness, impaired coordination, and slowed breathing.

Storage Conditions

Store below 30°C temperature & in a dry place, protected from light. Keep all medicines out of reach of children.