Adafil 10mg Tablet

Uses of Adafil 10mg Tablet

• Erectile Dysfunction
• Benign Prostatic Hyperplasia

How does Adafil 10mg Tablet work?

Adafil 10mg Tablet operates by inducing relaxation in the smooth muscles within the penis, consequently promoting enhanced blood flow. This mechanism facilitates the hardening of the penis and results in an erection. Moreover, Adafil 10mgTablet extends its muscle-relaxing effects to the muscles within the prostate gland and bladder. This dual action contributes to the amelioration of symptoms associated with benign prostatic hypertrophy (BPH), including heightened urinary frequency, challenges in urination, and a sluggish urine stream, among others.

Side Effects of Adafil 10mg Tablet

• Headache
• Back pain
• Muscle pain
• Pain in legs and arms
• Nasal congestion
• Indigestion
• Facial flushing

Quick Suggestions:

• It is best to take it an hour before sexual intercourse. But, you can take it anytime between 30 minutes and 4 hours before sexual activity.
• Do not take it more than once a day.
• Do not use Adafil 10mg Tablet if you have recently taken nitrates (medicines used in angina or chest pain).
• It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
• Avoid drinking alcohol as it can reduce your ability to get an erection and can make dizziness worse.
• Seek medical attention if the erection persists for more than 4 hours after sexual intercourse.
• Do not use Adafil 10mg Tablet if you have recently taken nitrates (medicines used in angina or chest pain), if you have had a heart attack in the past 3 months, or stroke or heart failure in the past 6 months.

Indication of Adafil 10mgTablet

Erectile Dysfunction: Erectile dysfunction, also known as impotence, refers to the inability of a man to achieve and/or sustain an erection sufficient for engaging in sexual intercourse. This condition arises due to reduced blood flow to the penis. The reduced blood flow can be a consequence of physical issues stemming from injuries, disorders, or psychological factors like anxiety, stress, depression, etc. Long-term lifestyle factors such as obesity, smoking, and alcohol consumption may also contribute to erectile dysfunction. Adafil 10mg Tablet is utilized for treating this condition.

Benign Prostatic Hyperplasia (BPH): Benign prostatic hyperplasia involves the non-cancerous enlargement of the prostate gland, a small organ positioned just beneath the bladder. This gland produces fluid that nourishes and transports sperm. When the prostate grows larger and presses against the urethra, it can lead to urinary symptoms such as difficulty urinating, weak urine flow, frequent urination, and loss of bladder control. Adafil 10mg Tablet is effective in alleviating the urinary symptoms associated with BPH.

Pulmonary Arterial Hypertension (PAH): Pulmonary arterial hypertension results in symptoms like shortness of breath, fatigue, dizziness, chest pain, and swelling in the ankles and legs. It emerges due to the thickening of the walls of arteries supplying blood to the lungs, causing blood flow obstruction. Adafil 10mg Tablet belongs to a category of medications called PDE5 inhibitors. Its action involves relaxing blood vessels, which aids in lowering blood pressure within the lung arteries. This can enhance your ability to carry out daily activities without excessive fatigue or dizziness. Consistent usage, as prescribed, is important even if you feel it's not effective or if you experience an improvement in your symptoms.

Pharmacology

Tadalafil is a specific inhibitor of phosphodiesterase type 5 (PDE5). PDE5 inhibition raises cGMP levels in smooth muscle cells. Smooth muscle relaxation and increased blood flow into the corpus cavernosum are both caused by cGMP, resulting in penile erection. PDE5 is also found in the prostate and bladder wall smooth muscles. PDE5 inhibition raises cGMP levels, causing smooth muscle relaxation in the prostate and bladder. Smooth muscle relaxation may enhance blood flow to the urinary system and widen the bladder neck opening, resulting in better voiding.

Dosage & Administration of Adafil 10mgTablet

For individuals dealing with different conditions, here are the recommended dosages and guidelines for using Adafil 10mg Tablet:

For Erectile Dysfunction:

• Most patients should commence with a starting dose of 10 mg.
• Depending on individual needs, the dose can be adjusted to either 20 mg or lowered to 5 mg.
• The highest frequency of dosing is once daily.
• Tadalafil remains effective for up to 36 hours.

For Benign Prostatic Hyperplasia:

• The advised dose is 5 mg, taken at the same time each day.

For Combined Erectile Dysfunction and Benign Prostatic Hyperplasia:

• The recommended dose is 5 mg, taken at the same time daily.

It is recommended to take Adafil 10mg Tablet preferably before meals and at least 1 hour before engaging in sexual activity, or as directed by your physician. Swallow the tablet with a glass of water, and do not crush or chew it.

The appropriate dosage and duration of therapy will be determined by your doctor, considering factors such as your age, body weight, and specific medical conditions. Always follow your doctor's guidance.

Interaction

Prior to using Adafil 10mg Tablet, it's imperative to inform your doctor if you are currently using any of the following medications:

• Bosentan or riociguat (prescribed for pulmonary arterial hypertension treatment)
• Nitrates or amyl nitrites (utilized for relieving chest pain) e.g., nitroglycerin, isosorbide dinitrate
• Alpha-blockers (prescribed for high blood pressure or benign prostatic hyperplasia treatment) e.g., prazosin, terazosin, tamsulosin
• Other medications for managing high blood pressure (like atenolol, propranolol, enalapril, and lisinopril)
• Ketoconazole, itraconazole (administered for treating fungal infections)
• Protease inhibitors (employed for HIV infection treatment) e.g., ritonavir, lopinavir
• Phenobarbital, phenytoin, carbamazepine (medicines used against seizures)
• Rifampicin, erythromycin, clarithromycin (medications used to combat bacterial infections)
• Other medicines designed for treating erectile dysfunction (e.g., sildenafil)

Additionally, there are interactions to consider with food:

• Refrain from consuming grapefruit juice while using Adafil 10mg Tablet, as it might heighten the risk of experiencing side effects.

Contraindications

Avoid using Adafil 10mg Tablet under the following circumstances:

• If you have an allergy to tadalafil or any other ingredient within the Adafil 10mg Tablet.
• If you possess a documented history of heart issues such as heart failure.
• If you have experienced a stroke within the last 6 months, suffered a heart attack within the past 90 days, or encountered breathlessness or chest pain during sexual activity.
• If you have a known history of liver disorders, low blood pressure, stroke, or heart blockage.
• If you have been previously diagnosed with eye problems, such as retinitis pigmentosa, which is a genetic disorder that may lead to vision loss.

Pregnancy & Lactation

Adafil 10mg Tablet is not intended for use in pregnant women.

Precautions & Warnings

Refrain from taking Adafil 10mg Tablet if you fall into the following categories:

• You have a history of heart problems, stroke, low blood pressure, uncontrolled high blood pressure, or a previous experience of vision loss.
• You possess sickle cell anemia (a condition involving abnormal red blood cells), multiple myeloma (a type of bone marrow cancer), leukemia (a form of blood cell cancer), deformities in the penis, or severe kidney or liver problems.
• In case you encounter loss of vision or hearing while taking Adafil 10mg Tablet, consult your doctor promptly.
• Be cautious while driving, as Adafil 10mg Tablet may induce dizziness. Alcohol consumption can intensify this effect.
• This medication is not appropriate for children due to a lack of established safety and effectiveness.
• Refrain from using if you are a known heart patient, have physical genital organ deformities, experience sudden vision or hearing loss, or encounter an erection lasting over 4 hours after taking the medicine.
• Adafil 10mg Tablet is not suitable for use in women.
• If you have kidney or liver issues, Adafil 10mg Tablet should be avoided.
• Children under 18 years of age should not use Adafil 10mg Tablet.

Storage Conditions

• Store Adafil 10mg Tablets in a cool and dry place.
• Keep it away from children and pets.