Acepril 5mg 14pcs - ePharma
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Acepril 5mg 14pcs

Type: Tablet

Pack Size: 14 Pcs

Type: Tab. Manufacturer/Distributor: Drug Inter. Generic Name: Lisinopril 5mg & 10mg/tablet


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Discount Price: ৳ 52.73
MRP: ৳ 56.7 7% Off

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Description:

Indications

Hypertension: Lisinopril is used to treat hypertension in adults and children aged 6 and up. It lowers blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, such as strokes and myocardial infarctions. Antihypertensive medicines from a wide range of pharmacologic classes have shown these advantages in controlled trials.

High blood pressure control should be part of a complete cardiovascular risk management strategy that includes, where needed, cholesterol control, diabetes management, antithrombotic treatment, smoking cessation, exercise, and sodium restriction. To meet blood pressure targets, many individuals will require more than one medicine. See published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, for detailed advice on goals and management (JNC).

In randomized controlled trials, a variety of antihypertensive drugs from various pharmacologic classes and with various mechanisms of action have been shown to reduce cardiovascular morbidity and mortality, and it can be concluded that blood pressure reduction, not some other pharmacologic property of the drugs, is largely responsible for those benefits. The reduction in the risk of stroke has been the most significant and consistent cardiovascular outcome benefit, but reductions in myocardial infarction and cardiovascular mortality have also been shown on a regular basis.

Lisinopril is used to treat heart failure symptoms in patients who aren't responding well to diuretics or digitalis.

Acute Myocardial Infarction: Lisinopril is used to reduce mortality in hemodynamically stable patients who have had an acute myocardial infarction within the first 24 hours. Standard suggested treatments such as thrombolytics, aspirin, and beta-blockers should be given to patients as needed.

 

Pharmacology

Lisinopril inhibits ACE from converting angiotensin I to angiotensin II (a potent vasoconstrictor), resulting in higher plasma renin activity and lower aldosterone secretion (a hormone that causes water and sodium retention). This causes vasodilation and lowers blood pressure.

 

Dosage & Administration

Oral (Adult)-

Hypertension: Initially, 10 mg/day, 1st dose given preferably at bedtime to avoid precipitous fall in BP. Patient with renovascular HTN, volume depletion, severe HTN: Initially, 2.5-5 mg once daily. Patient on diuretic: Initially, 5 mg once daily. Maintenance: 20 mg once daily, up to 80 mg/day may be given if needed.

Diabetic nephropathy: Hypertensive type 2 diabetics with microalbuminuria: 10 mg once daily, may increase to 20 mg once daily to achieve a sitting diastolic BP

Heart failure: As adjunct: Initially, 2.5 or 5 mg/day, increased by increments of ≤10 mg at intervals of at least 2 wk to max maintenance dose of 40 mg/day.

Post-myocardial infarction: Initially, 5 mg once daily for 2 days started within 24 hr of the onset of symptoms. Increase to 10 mg once daily. Patients with low systolic BP: Initially, 2.5 mg once daily.

Oral (Child)-

Hypertension: ≥6 yr Initially, 0.07 mg/kg, up to 5 mg once daily.

 

Interaction

Diuretics may enhance the hypotensive effect. NSAIDs, it may increase the risk of renal function deterioration and reduce the antihypertensive effect. Lithium toxicity and serum levels may be affected. Hyperkalemia is a risk with K-sparing diuretics and K supplements. Gold Na thiomalate nitrite reactions may be boosted.

 

Contraindications

Previous ACE inhibitor treatment-related angioedema, hereditary or idiopathic angioedema. In patients with diabetes or renal impairment, aliskiren should be used together. Pregnancy. Children with a GFR of less than 30 mL/min/1.73 m2

 

Side Effects

Headache, fatigue, chest and abdominal pain, dizziness, nausea, vomiting, diarrhea, upper respiratory tract infection, asthenia, rash, orthostatic effects, hypotension, renal dysfunction, hyperkalemia, intestinal angioedema; increased BUN and serum creatinine levels.

Pregnancy & Lactation

Category D: Although there is evidence of human fetal risk, the benefits of use in pregnant women may outweigh the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Precautions & Warnings

Bilateral renal artery stenosis or unilateral renal artery stenosis in a single kidney. Patients with collagen vascular disease and acute MI are at risk of worsening hemodynamics, angioedema not related to ACE inhibitor therapy, aortic stenosis, and hypertrophic cardiomyopathy. Angioedema risk is higher in black patients. Renal insufficiency. Lactation. 6 yr. old child

Storage Conditions

Store at a temperature of less than 25° C.

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Check our pricing section for Acepril 5mg 14pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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