Methotrax 10 | Methotrexate | Uses | Dosage | 10's | Price | ePharma
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Methotrax 10mg 10pcs

Generic: Methotrexate

Type: Tablet

Pack Size: 10 Pcs

Methotrax 10 is used for rheumatoid arthritis and severe psoriasis, preventing further joint damage and controlling skin cell overgrowth.


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Discount Price: ৳ 139.5
MRP: ৳ 150 7% Off

⪼ Save  ৳: 10.5  in this Product


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Description:

Neoplastic Diseases:

  • Treatment of gestational choriocarcinoma, chorioadenoma destruens, and hydatidiform mole.
  • Acute lymphoblastic leukemia in combination with other chemotherapeutic agents.
  • Advanced stage non-Hodgkin’s lymphomas.
  • Breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides, and lung cancer.

Rheumatoid Arthritis:

  • Management of selected adults with severe, active rheumatoid arthritis.
  • Children with active polyarticular-course juvenile rheumatoid arthritis, intolerant of first-line therapy.

Psoriasis:

  • Symptomatic control of severe, recalcitrant, disabling psoriasis not adequately responsive to other forms of therapy.

Safety Advices


Alcohol

Caution is advised when consuming alcohol with Methotrax 10 mg. Consult your doctor.


Pregnancy
UNSAFE
  • Methotrax 10 mg is highly unsafe during pregnancy.
  • Seek your doctor's advice as studies indicate significant harmful effects on the developing baby in both pregnant women and animals.

Breastfeeding
UNSAFE
  • Methotrax 10 mg is unsafe during breastfeeding.
  • Data suggests potential toxicity to the baby.

Driving
UNSAFE
  • Methotrax 10 mg may decrease alertness, affect vision, or induce drowsiness and dizziness.
  • Do not drive if experiencing these symptoms.

Kidney
CAUTION
  • Use Methotrax 10 mg with caution in patients with kidney disease.
  • Dose adjustment may be necessary; consult your doctor.
  • Regular monitoring of kidney function is advised during the medication.

Liver
CAUTION
  • Methotrax 10 mg should be used with caution in patients with liver disease.
  • Dose adjustment may be needed; consult your doctor.
  • Use is not recommended in patients with severe liver disease.

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Uses of
  • Rheumatoid Arthritis and Psoriasis
How does

Methotrax 10 is an immunosuppressant, decreasing immune system activity. In psoriasis, it slows rapid skin cell growth.

Side Effects of

Abdominal pain, Indigestion, Loss of appetite, Nausea, Vomiting, Tiredness, Mouth sore.

Quick Suggestions:
  • Take weekly, same day; stay hydrated.
  • Consume folic acid to reduce side effects.
  • Effects may take weeks; continue as prescribed.
  • Avoid alcohol; harmful during pregnancy.
  • Harmful to an unborn baby; avoid pregnancy.
Indications:

Burkitt's lymphoma, Choriocarcinoma, Mycosis fungoides, Crohn's disease, Psoriasis, Osteosarcoma, Breast cancer, Acute lymphoblastic leukaemia, Rheumatoid arthritis.

Pharmacology:

Methotrax 10 mg inhibits dihydrofolic acid reductase, interfering with DNA synthesis, repair, and cellular replication. It impairs malignant growth in actively proliferating tissues, more sensitive in malignant cells.

Dosage & Administration:

Neoplastic Diseases-Choriocarcinoma and similar trophoblastic diseases:

  • Orally or intramuscularly, 15 to 30 mg daily for a five-day course.
  • Courses are repeated 3 to 5 times as required, with rest periods of one or more weeks.
  • Prophylactic chemotherapy is recommended for hydatidiform mole.

Acute Lymphoblastic Leukemia:

  • Induction dose: 3.3 mg/m2 with prednisone 60 mg/m2 daily for 4 to 6 weeks.
  • Maintenance dose: Orally or IM administration 2 times a week (total weekly doses of 30 mg/m2).
  • Alternate maintenance dose: 2.5 mg/kg IV every 14 days.

Lymphoma Burkitt's tumor:

  • Stages I to II: 10 to 25 mg once a day for 4 to 8 days.
  • Stage III: Concomitant with other antitumor agents.
  • Duration of therapy: Several courses with 7 to 10-day rest periods.

Lymphosarcoma Stage III:

  • 0.625 to 2.5 mg/kg daily as part of combination chemotherapy.

Mycosis fungicides:

  • Early stage dosing: 5 to 50 mg once a week or 15 to 37.5 mg 2 times a week.

Breast Cancer:

  • 40 mg/m2 intravenously on the 1st and 8th day every 4 weeks in combination with cyclophosphamide and fluorouracil for 6-12 cycles.

Head and Neck Cancer:

  • 40 mg/m2 IV weekly until disease progression or unacceptable toxicity (3 weeks equals one cycle; the goal is to complete at least six cycles).

Adult Rheumatoid Arthritis:

  • Single doses of 7.5 mg once per week, Maximum dose: 20 mg/week in adults.

Polyarticular-Course Juvenile Rheumatoid Arthritis:

  • 10 mg/m2 once weekly.

Psoriasis:

  • Single dose: 10 to 25 mg once per week, maximum dose: 30 mg/week.

Administration of Methotrax 10 mg:

  • Should be taken on an empty stomach. Best taken on an empty stomach.
  • May be taken with meals to reduce GI discomfort.
  • Avoid taking milk-rich products.
Interaction
  • NSAIDs: Avoid before or concomitantly with high doses of Methotrax 10 mg.
  • Salicylates, Phenylbutazone, Phenytoin, Sulfonamides: Increased toxicity.
  • Monitoring is advised with Penicillin, Theophylline, Probenecid, Azathioprine, Retinoids, and Sulfasalazine.
  • Caution with Cisplatin; increased plasma levels of mercaptopurine.
  • Interaction with Tetracycline, Chloramphenicol, Nonabsorbable Broad Spectrum Antibiotics, Vitamin preparations containing folic acid or its derivatives, Trimethoprim/Sulfamethoxazole.
Contraindications
  • Alcoholism, alcoholic liver disease, or other chronic liver disease.
  • Immunodeficiency syndromes.
  • Pre-existing blood dyscrasias, bone marrow hypoplasia, leukopenia, thrombocytopenia, or significant anemia.
  • Hypersensitivity to Methotrax 10 mg.
  • Pregnant women with psoriasis or rheumatoid arthritis.
  • Women of childbearing potential.
  • Nursing mothers.
  • Pregnancy should be avoided during and after therapy.
Pregnancy & Lactation

Pregnancy category X. Contraindicated in pregnant and nursing women.

Precautions & Warnings
  • Methotrax 10 mg formulations and diluents with preservatives must not be used for intrathecal or high-dose therapy.
  • Close monitoring for toxic effects is required.
  • Reduce dosage or discontinue if adverse reactions occur.
  • Caution with reinstitution of Methotrax 10 mg therapy.
  • Evaluation for persistent liver function test abnormalities, and depression of serum albumin.
  • Folate deficiency may increase Methotrax 10 mg toxicity.
Overdose Effects of Methotrax 10 mg:

Leucovorin is indicated to diminish the toxicity and counteract inadvertent overdosages. Administer promptly.

Storage Conditions

Store at a temperature not exceeding 30°C in a dry place. Protect from light & moisture.

Frequently Asked Questions (FAQ)

Methotrax 10 is indicated for the treatment of psoriasis and rheumatoid arthritis, in patients who have tried other treatments but whose illness has not improved

The time taken for Methotrexate 2.5 MG Tablet to show its effect is not known.

No

No
Ratings & Reviews

No review

Check our pricing section for Methotrax 10mg 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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